Genome editing has been a transformative force in the life sciences and human medicine,
offering unprecedented opportunities to dissect complex biological processes and treat the …

Immune rejection is an important obstacle to the use of allogeneic 'off-the-shelf'cells for
transplantation into immunocompetent patients. Genetic modification has emerged as a …

Background Precise gene targeting (GT) is a powerful tool for heritable precision genome
engineering, enabling knock-in or replacement of the endogenous sequence via …

CRISPR-Cas induced homology-directed repair (HDR) enables the installation of a broad
range of precise genomic modifications from an exogenous donor template. However …

Lactobacillus, a genus of lactic acid bacteria, plays a crucial function in food production
preservation, and probiotics. It is particularly important to develop new Lactobacillus strains …

Homing CRISPR gene drives could aid in curbing the spread of vector-borne diseases and
controlling crop pest and invasive species populations due to an inheritance rate that …

Sickle cell disease (SCD) is an inherited blood disorder, due to a single point mutation in the
β-globin gene (HBB) leading to multisystemic manifestations and it affects millions of people …

Cancer variant modeling in vivo | Nature Biotechnology Skip to main content Thank you for
visiting nature.com. You are using a browser version with limited support for CSS. To obtain the …

Gene editing characterization with currently available tools does not always give precise
relative proportions among the different types of gene edits present in an edited bulk of cells …

Respiratory disorders are among the conditions that affect the respiratory system. The
healthcare sector faces challenges due to the emergence of drug resistance to prescribed …