A critical perspective on 3D liver models for drug metabolism and toxicology studies
AS Serras, JS Rodrigues, M Cipriano… - Frontiers in cell and …, 2021 - frontiersin.org
The poor predictability of human liver toxicity is still causing high attrition rates of drug
candidates in the pharmaceutical industry at the non-clinical, clinical, and post-marketing …
candidates in the pharmaceutical industry at the non-clinical, clinical, and post-marketing …
An overview of the evidence and mechanisms of herb–drug interactions
PS Fasinu, PJ Bouic, B Rosenkranz - Frontiers in pharmacology, 2012 - frontiersin.org
Despite the lack of sufficient information on the safety of herbal products, their use as
alternative and/or complementary medicine is globally popular. There is also an increasing …
alternative and/or complementary medicine is globally popular. There is also an increasing …
Clearance prediction methodology needs fundamental improvement: trends common to rat and human hepatocytes/microsomes and implications for experimental …
FL Wood, JB Houston, D Hallifax - Drug Metabolism and Disposition, 2017 - ASPET
Although prediction of clearance using hepatocytes and liver microsomes has long played a
decisive role in drug discovery, it is widely acknowledged that reliably accurate prediction is …
decisive role in drug discovery, it is widely acknowledged that reliably accurate prediction is …
ITC recommendations for transporter kinetic parameter estimation and translational modeling of transport‐mediated PK and DDIs in humans
MJ Zamek‐Gliszczynski, CA Lee… - Clinical …, 2013 - Wiley Online Library
This white paper provides a critical analysis of methods for estimating transporter kinetics
and recommendations on proper parameter calculation in various experimental systems …
and recommendations on proper parameter calculation in various experimental systems …
Cell cultures in drug discovery and development: The need of reliable in vitro-in vivo extrapolation for pharmacodynamics and pharmacokinetics assessment
For ethical and cost-related reasons, use of animals for the assessment of mode of action,
metabolism and/or toxicity of new drug candidates has been increasingly scrutinized in …
metabolism and/or toxicity of new drug candidates has been increasingly scrutinized in …
Evaluation of pharmacokinetic drug–drug interactions: a review of the mechanisms, in vitro and in silico approaches
Y Peng, Z Cheng, F Xie - Metabolites, 2021 - mdpi.com
Pharmacokinetic drug–drug interactions (DDIs) occur when a drug alters the absorption,
transport, distribution, metabolism or excretion of a co-administered agent. The occurrence …
transport, distribution, metabolism or excretion of a co-administered agent. The occurrence …
Successful and unsuccessful prediction of human hepatic clearance for lead optimization
Development of new chemical entities is costly, time-consuming, and has a low success
rate. Accurate prediction of pharmacokinetic properties is critical to progress compounds …
rate. Accurate prediction of pharmacokinetic properties is critical to progress compounds …
Prediction of organic anion-transporting polypeptide 1B1-and 1B3-mediated hepatic uptake of statins based on transporter protein expression and activity data
A Kunze, J Huwyler, G Camenisch, B Poller - Drug Metabolism and …, 2014 - ASPET
Organic anion-transporting polypeptides (OATP) 1B1 and OATP1B3 are drug transporters
mediating the active hepatic uptake of their substrates. Because they exhibit overlapping …
mediating the active hepatic uptake of their substrates. Because they exhibit overlapping …
Sandwich-cultured hepatocytes: utility for in vitro exploration of hepatobiliary drug disposition and drug-induced hepatotoxicity
T De Bruyn, S Chatterjee, S Fattah… - Expert opinion on …, 2013 - Taylor & Francis
Introduction: The sandwich-cultured hepatocyte (SCH) model has become an invaluable in
vitro tool for studying hepatic drug transport, metabolism, biliary excretion and toxicity. The …
vitro tool for studying hepatic drug transport, metabolism, biliary excretion and toxicity. The …
Interpretation of non-clinical data for prediction of human pharmacokinetic parameters: in vitro-in vivo extrapolation and allometric scaling
Extrapolation of pharmacokinetic (PK) parameters from in vitro or in vivo animal to human is
one of the main tasks in the drug development process. Translational approaches provide …
one of the main tasks in the drug development process. Translational approaches provide …