The most dramatic changes in eukaryotic cytoskeletal organization and dynamics occur
during passage through mitosis. Although both spindle self-organization and actin …

Higher-order actin-based networks (actin superstructures) are important for growth-cone
motility and guidance. Principles for generating, organizing and remodelling actin …

Mutations in the LRRK2 (leucine-rich repeat kinase-2) gene cause late-onset PD
(Parkinson's disease). LRRK2 contains leucine-rich repeats, a GTPase domain, a COR [C …

Background During mitosis, animal cells undergo a complex sequence of morphological
changes, from retraction of the cell margin and cell rounding at the onset of mitosis to axial …

ERM (Ezrin, Radixin, Moesin) proteins are membrane–cytoskeleton linkers that regulate the
structure and the function of specific domains of the plasma membrane. ERM proteins are …

Ezrin is a member of the ERM (ezrin, radixin, moesin) protein family and links F-actin to the
cell membrane following phosphorylation. Ezrin has been associated with tumor …

G protein-coupled receptor kinase 2 (GRK2) phosphorylates and desensitizes activated G
protein-coupled receptors (GPCRs). Here, we identify ezrin as a novel non-GPCR substrate …

Ezrin/radixin/moesin (ERM) family members provide a regulated link between the cortical
actin cytoskeleton and the plasma membrane to govern membrane structure and …

The physical interaction of the plasma membrane with the associated cortical cytoskeleton is
important in many morphogenetic processes during development. At the end of the syncytial …

The cytoskeleton plays a key role in maintaining the highly asymmetrical shape and
structural polarity of neurons that are essential for neuronal physiology. Cytoskeletal …