Immune escape of avian oncogenic Marek's disease herpesvirus and antagonistic host immune responses

ZJ Zhu, M Teng, Y Liu, FJ Chen, Y Yao, EZ Li, J Luo - npj Vaccines, 2024 - nature.com
Marek's disease virus (MDV) is a highly pathogenic and oncogenic alpha herpesvirus that
causes Marek's disease (MD), which is one of the most important immunosuppressive and …

A single amino acid at residue 188 of the hexon protein is responsible for the pathogenicity of the emerging novel virus fowl adenovirus 4

Y Zhang, A Liu, Y Wang, H Cui, Y Gao, X Qi… - Journal of …, 2021 - Am Soc Microbiol
Since 2015, severe hydropericardium-hepatitis syndrome (HHS) associated with a novel
fowl adenovirus 4 (FAdV-4) has emerged in China, representing a new challenge for the …

Pros and Cons on Use of Live Viral Vaccines in Commercial Chicken Flocks

K Ganapathy, S Parthiban - Avian Diseases, 2024 - meridian.allenpress.com
The poultry industry is the largest source of meat and eggs for the growing human
population worldwide. Key concerns in poultry farming are nutrition, management, flock …

Fully Attenuated meq and pp38 Double Gene Deletion Mutant Virus Confers Superior Immunological Protection against Highly Virulent Marek's Disease Virus …

A Sun, X Zhao, X Zhu, Z Kong, Y Liao… - Microbiology …, 2022 - Am Soc Microbiol
Marek's disease virus (MDV) induces immunosuppression and neoplastic disease in
chickens. The virus is controllable via an attenuated meq deletion mutant virus, which has …

Onset and long-term duration of immunity provided by a single vaccination with recombinant a Marek's disease virus with REV-LTR insertion

J Dai, C Song, L Tan, Y Sun, N Tang, Y Qu… - Frontiers in Veterinary …, 2024 - frontiersin.org
Marek's Disease (MD), caused by Marek's disease virus (MDV), is a highly contagious
lymphoproliferative disease in poultry. Despite the fact that MD has been effectively …

Methods for the Manipulation of Herpesvirus Genome and the Application to Marek's Disease Virus Research

Y Liao, K Bajwa, SM Reddy, B Lupiani - Microorganisms, 2021 - mdpi.com
Herpesviruses are a group of double-strand DNA viruses that infect a wide range of hosts,
including humans and animals. In the past decades, numerous methods have been …

Report of a new meq gene size: The first study on genetic characterisation of Marek's disease viruses circulating in Iranian commercial layer and backyard chicken

A Molouki, A Ghalyanchilangeroudi… - British Poultry …, 2022 - Taylor & Francis
In recent months, several outbreaks with clinical signs of MDV-1 were reported in Iranian
parent and laying hen farms, in addition to backyard chickens. Several meq gene …

The First Record of an Aggressive Form of Ocular Tumour Enhanced by Marek's Disease Virus Infection in Layer Flock in Al‐Najaf, Iraq

A Al-Zebeeby, AH Abbas, HA Alsaegh… - Veterinary Medicine …, 2024 - Wiley Online Library
Marek's disease (MD) is a highly infectious poultry illness with a tendency to form tumours in
peripheral nerves and internal organs of affected birds. Tumours accompany MD, mostly …

Current Status of Poultry Recombinant Virus Vector Vaccine Development

H Wang, J Tian, J Zhao, Y Zhao, H Yang, G Zhang - Vaccines, 2024 - mdpi.com
Inactivated and live attenuated vaccines are the mainstays of preventing viral poultry
diseases. However, the development of recombinant DNA technology in recent years has …

Latest insights into unique open reading frames encoded by Unique Long (UL) and Short (US) regions of Marek's Disease Virus

Y Liao, B Lupiani, SM Reddy - Viruses, 2021 - mdpi.com
Marek's disease virus (MDV) is an oncogenic avian alphaherpesvirus whose genome
consists of unique long (UL) and short (US) regions that are flanked by inverted repeat …