Voltage-gated ion channels are important mediators of physiological functions in the central
nervous system. The cyclic activation of these channels influences neurotransmitter release …

Neurological disorders including depression, anxiety, post-traumatic stress disorder (PTSD),
schizophrenia, autism and epilepsy are associated with an increased incidence of …

The specific functions of sensory systems depend on the tissue-specific expression of genes
that code for molecular sensor proteins that are necessary for stimulus detection and …

The ERG1 potassium channel, encoded by KCNH2, has long been associated with cardiac
electrical excitability. Yet, a growing body of work suggests that ERG1 mediates physiology …

Background Autism spectrum disorder (ASD) is highly heritable, yet genome-wide
association studies (GWAS), copy number variation screens, and candidate gene …

Schizophrenia has been considered a devastating clinical syndrome rather than a single
disease. Nevertheless, the mechanisms behind the onset of schizophrenia have been only …

While cholinergic receptor activation has long been known to dramatically enhance the
excitability of cortical neurons, the cellular mechanisms responsible for this effect are not …

Patients with schizophrenia show decreased processing speed on neuropsychological
testing and decreased white matter integrity as measured by diffusion tensor imaging, two …

Objective: Antipsychotic drugs target dopamine and serotonin receptors as well as Kv11. 1
potassium channels encoded by KCNH2. Variable patient responses and a wide range of …

Objective Identification of genetic variants that influence bipolar I disorder (BPD-I) through
genome-wide association (GWA) studies is limited in Asian populations. The current study …