Worldwide, breast cancer is the leading cause of cancer-related deaths in women. Breast
cancer is a heterogeneous disease characterized by different clinical outcomes in terms of …

This review focuses on genes other than the high penetrance genes BRCA1 and BRCA2
that are involved in breast cancer susceptibility. The goal of this review is the discovery of …

High-throughput DNA sensors capable of detecting single-base mismatches are required for
the routine screening of genetic mutations and disease. A new strategy for the …

I. Regulation of Mammary Cell Growth and Apoptosis A. Hormonal control of mammary
development, proliferation, and lactational defferentation D EVELOPMENT of the normal …

We report that transfection of insulin-like growth factor-binding protein-3 (IGFBP-3) cDNA in
human breast cancer cell lines expressing either mutant p53 (T47D) or wild-type p53 (MCF …

The seemingly ubiquitous presence of p53 mutations in human tumors has thrust this
previously unheralded tumor suppressor gene into the limelight. While not all human tumors …

Breast and ovarian cancers, like other cancers, occur due to genetic damage. Research
aimed to determine the specific genes involved in the development of breast and ovarian …

Molecular Biology of Cancer has been extensively revised and covers heredity cancer,
microarray technology and increased study of childhood cancers. It continues to provide a …

Abstract The Li-Fraumeni familial cancer syndrome was initially described in 1969 in a
retrospective epidemiologic review of more than 600 pediatric sarcoma patients. The clinical …

Point mutations in the p53 gene have been detected in a variety of human cancers; the
mutations are clustered in four" hot-spots" located in the coding region of exons 5, 7, and 8 …