Amorphous solid dispersion (ASD) is one of the most important strategies to improve the
solubility and dissolution rate of poorly water-soluble drugs. As a widely used technique to …

Taste-masking of drugs, particularly to produce formulations for pediatric patients, can be
challenging and require complex manufacturing approaches. The objective of this study was …

Chemical degradation of drug substances remains a major drawback of extrusion. Larger-
scale extrusion equipment has advantages over smaller equipment due to deeper flight …

Twin-screw extrusion (TSE) is being adopted by the pharmaceutical industry at an
unprecedented pace, mainly due to its highly efficient continuous processing with …

Hydroxypropyl methylcellulose acetate succinate (HPMCAS) is an excellent polymeric
carrier for melt extrusion amorphous solid dispersion. However, its pH-dependent solubility …

A novel solvent controlled precipitation (SCP) process based on microfluidization was
assessed to produce solid dispersions of carbamazepine, a poorly water-soluble drug with …

Techniques to overcome poor aqueous solubility of active pharmaceutical ingredients (APIs)
continue to gain interest with a reported 30% of marketed compounds classified as BCS II …

Pharmaceutical dosage form design and product development requires a wide range of
expertise and background knowledge. The working process starts from a disease target …

Techniques to overcome poor aqueous solubility of active pharmaceutical ingredients (APIs)
continue to gain interest, with a reported 30% of marketed compounds classified as BCS II …

Solid dosage forms, such as tablets, capsules, and powder, are one of the most widely used
administration methods for drug delivery. However, scientists and researchers are facing …