Endocrine cells within the pancreatic islets of Langerhans are heterogeneous in terms of
transcriptional profile, protein expression and the regulation of hormone release. Even …

Simple Summary Pancreatic islets are micro-organs composed of several endocrine cell
types, including α-cells (secreting glucose-elevating glucagon), β-cells (releasing glucose …

Dopamine (DA) and norepinephrine (NE) are catecholamines primarily studied in the central
nervous system that also act in the pancreas as peripheral regulators of metabolism …

Dysfunction of pancreatic δ cells contributes to the etiology of diabetes. Despite their
important role, human δ cells are scarce, limiting physiological studies and drug discovery …

Diabetes mellitus involves both insufficient insulin secretion and dysregulation of glucagon
secretion. In healthy people, a fall in plasma glucose stimulates glucagon release and …

Aims/hypothesis Diabetes mellitus is associated with impaired insulin secretion, often
aggravated by oversecretion of glucagon. Therapeutic interventions should ideally correct …

Recent developments suggest that increased glucagon and decreased somatostatin
secretion from the pancreas contribute to hyperglycaemia in type-2 diabetes (T2D) patients …

Objectives Elevated plasma glucagon is an early symptom of diabetes, occurring in subjects
with impaired glucose regulation. Here, we explored alpha-cell function in female mice fed a …

The semi‐essential ubiquitous amino acid taurine has been shown to alleviate obesity and
hyperglycemia in humans; however, the pathways underlying the antidiabetic actions have …

The pancreatic islets of Langerhans secrete several hormones critical for glucose
homeostasis. The β-cells, the major cellular component of the pancreatic islets, secrete …