Bulk sequencing methodologies have allowed us to make great progress in cancer
research. Unfortunately, these techniques lack the resolution to fully unravel the epigenetic …

In the past decade, remarkable progress in cancer medicine has been achieved by the
development of treatments that target DNA sequence variants. However, a purely genetic …

We previously described an approach called RealSeqS to evaluate aneuploidy in plasma
cell-free DNA through the amplification of~ 350,000 repeated elements with a single primer …

Background Previous studies have traditionally attributed the initiation of cancer cells to
genetic mutations, considering them as the fundamental drivers of carcinogenesis. However …

Simple Summary Cancer is a distinctly difficult disease to treat on account of the diverse cell
populations/subpopulations that comprise a tumour. Such cells harbour varying genetic and …

As one of the most common tumors in women, the pathogenesis and tumor heterogeneity of
breast cancer have long been the focal point of research, with the emergence of tumor …

Single cell sequencing technologies have become a fixture in the molecular profiling of cells
due to their ease, flexibility, and commercial availability. In particular, partitioning individual …

Background The HLA-DRB1 gene in the major histocompatibility complex (MHC) region in
chromosome 6p21 is the strongest genetic factor identified as influencing multiple sclerosis …

Despite recent progress in identifying the genetic drivers of acute lymphoblastic leukemia
(ALL), prognosis remains poor for those individuals who experience disease recurrence …

Among various therapeutic agents, Oncolytic Viruses (OVs) are the most promising
anticancer therapeutics because of their tumor-specific targeting and capability to mediate …