Contemporary bioinformatics and cheminformatics support for food peptidomics

P Minkiewicz, A Iwaniak, M Darewicz - Current Opinion in Food Science, 2024 - Elsevier
Highlights•Food peptidomics is extensively supported by in silico tools.•Both bioinformatics
and cheminformatics tools are useful in food peptidomics.•Food peptidomics needs tools …

AlphaFold2 in biomedical research: facilitating the development of diagnostic strategies for disease

H Zhang, J Lan, H Wang, R Lu, N Zhang… - Frontiers in Molecular …, 2024 - frontiersin.org
Proteins, as the primary executors of physiological activity, serve as a key factor in disease
diagnosis and treatment. Research into their structures, functions, and interactions is …

Multi-epitope peptide vaccines targeting dengue virus serotype 2 created via immunoinformatic analysis

RN Morgan, NSM Ismail, MY Alshahrani… - Scientific Reports, 2024 - nature.com
Abstract The Middle East has witnessed a greater spread of infectious Dengue viruses, with
serotype 2 (DENV-2) being the most prevalent form. Through this work, multi-epitope …

Design of a covalent protein-protein interaction inhibitor of SRPKs to suppress angiogenesis and invasion of cancer cells

G Cai, Y Bao, Q Li, PH Hsu, J Xia… - Communications Chemistry, 2024 - nature.com
Serine–arginine (SR) proteins are splicing factors that play essential roles in both
constitutive and alternative pre-mRNA splicing. Phosphorylation of their C-terminal RS …

Expanding the phenotype of THRB: a range of macular dystrophies as the major clinical manifestations in patients with a dominant splicing variant

E Fernández-Suárez, M González-del Pozo… - Frontiers in Cell and …, 2023 - frontiersin.org
Inherited retinal dystrophies (IRDs) are a clinically and genetically heterogeneous group of
disorders that often severely impair vision. Some patients manifest poor central vision as the …

[HTML][HTML] Unveiling the interaction between DNA G-quadruplexes and RG-rich peptides

N Grasso, R Graziano, S Marzano, F D'Aria… - International Journal of …, 2023 - Elsevier
G-quadruplexes are non-canonical DNA secondary structures formed within guanine-rich
strands that play important roles in various biological processes, including gene regulation …

[HTML][HTML] A Novel Bacitracin-like Peptide from Mangrove-Isolated Bacillus paralicheniformis NNS4-3 against MRSA and Its Genomic Insights

N Sermkaew, A Atipairin, T Wanganuttara, S Krobthong… - Antibiotics, 2024 - mdpi.com
The global rise of antimicrobial resistance (AMR) presents a critical challenge necessitating
the discovery of novel antimicrobial agents. Mangrove microbes are valuable sources of …

Novel ACE inhibitory peptides from enzymatic hydrolysate of Channa punctata protein: In vitro and In silico assay of structure-activity relationship

M Das, A Gangopadhyay, A Saha, P Dhar - Food Bioscience, 2024 - Elsevier
Channa punctata flesh meat is well known for its ethnomedicinal values. The objective of
this study was to isolate and identify peptides having Angiotensin-Converting Enzyme (ACE) …

[HTML][HTML] A Novel Workflow for In Silico Prediction of Bioactive Peptides: An Exploration of Solanum lycopersicum By-Products

F Morena, C Cencini, E Calzoni, S Martino, C Emiliani - Biomolecules, 2024 - mdpi.com
Resource-intensive processes currently hamper the discovery of bioactive peptides (BAPs)
from food by-products. To streamline this process, in silico approaches present a promising …

Influence of Aza-Glycine substitution on the internalization of penetratin

K Tarchoun, D Soltész, V Farkas, HJ Lee, I Szabó… - Pharmaceutics, 2024 - mdpi.com
The cell-penetrating peptide (CPP) penetratin has gained much attention over many years
due to its potential role as a transporter for a broad range of cargo into cells. The …