Neurogenesis in aging and age-related neurodegenerative diseases
Adult neurogenesis, the process by which neurons are generated in certain areas of the
adult brain, declines in an age-dependent manner and is one potential target for extending …
adult brain, declines in an age-dependent manner and is one potential target for extending …
Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases
Apolipoprotein (apo) E is a multifunctional protein with central roles in lipid metabolism,
neurobiology, and neurodegenerative diseases. It has three major isoforms (apoE2, apoE3 …
neurobiology, and neurodegenerative diseases. It has three major isoforms (apoE2, apoE3 …
Peripheral apoE4 enhances Alzheimer's pathology and impairs cognition by compromising cerebrovascular function
The ε4 allele of the apolipoprotein E (APOE) gene, a genetic risk factor for Alzheimer's
disease, is abundantly expressed in both the brain and periphery. Here, we present …
disease, is abundantly expressed in both the brain and periphery. Here, we present …
[HTML][HTML] Alzheimer mechanisms and therapeutic strategies
There are still no effective treatments to prevent, halt, or reverse Alzheimer's disease, but
research advances over the past three decades could change this gloomy picture. Genetic …
research advances over the past three decades could change this gloomy picture. Genetic …
Mouse models of Alzheimer's disease
G Esquerda-Canals, L Montoliu-Gaya… - Journal of …, 2017 - content.iospress.com
Alzheimer's disease (AD) is a neurodegenerative disorder that nowadays affects more than
40 million people worldwide and it is predicted to exponentially increase in the coming …
40 million people worldwide and it is predicted to exponentially increase in the coming …
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits
V Jevtovic-Todorovic, RE Hartman, Y Izumi… - Journal of …, 2003 - Soc Neuroscience
Recently it was demonstrated that exposure of the developing brain during the period of
synaptogenesis to drugs that block NMDA glutamate receptors or drugs that potentiate …
synaptogenesis to drugs that block NMDA glutamate receptors or drugs that potentiate …
The role of apolipoprotein E in Alzheimer's disease
The ɛ4 allele of apolipoprotein E (APOE) is the major genetic risk factor for Alzheimer's
disease (AD). Although there have been numerous studies attempting to elucidate the …
disease (AD). Although there have been numerous studies attempting to elucidate the …
Cholesterol metabolism in neurons and astrocytes
FW Pfrieger, N Ungerer - Progress in lipid research, 2011 - Elsevier
Cells in the mammalian body must accurately maintain their content of cholesterol, which is
an essential membrane component and precursor for vital signalling molecules. Outside the …
an essential membrane component and precursor for vital signalling molecules. Outside the …
Apolipoprotein e sets the stage: response to injury triggers neuropathology
Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer's disease and is
associated with poor clinical outcome following traumatic brain injury and other …
associated with poor clinical outcome following traumatic brain injury and other …
Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes
WS Chung, PB Verghese… - Proceedings of the …, 2016 - National Acad Sciences
The strongest genetic risk factor influencing susceptibility to late-onset Alzheimer's disease
(AD) is apolipoprotein E (APOE) genotype. APOE has three common isoforms in humans …
(AD) is apolipoprotein E (APOE) genotype. APOE has three common isoforms in humans …