Clinical trials evaluating medicines, medical devices, and procedures now commonly
assess the economic value of these interventions. The growing number of prospective …

Clinical trials identified intravitreal vascular endothelial growth factor inhibitors (anti-VEGF
agents) have the potential to stabilise or even improve visual acuity outcomes in …

Background The management of complex orthopedic infections usually includes a
prolonged course of intravenous antibiotic agents. We investigated whether oral antibiotic …

Background The efficacy of fusion surgery in addition to decompression surgery in patients
who have lumbar spinal stenosis, with or without degenerative spondylolisthesis, has not …

Missing data are a frequent problem in cost-effectiveness analysis (CEA) within a
randomised controlled trial. Inappropriate methods to handle missing data can lead to …

The R package mice imputes incomplete multivariate data by chained equations. The
software mice 1.0 appeared in the year 2000 as an S-PLUS library, and in 2001 as an R …

The goal of multiple imputation is to provide valid inferences for statistical estimates from
incomplete data. To achieve that goal, imputed values should preserve the structure in the …

Background Research on the relationship between Health Related Quality of Life (HRQoL)
and physical activity (PA), to date, have rarely investigated how this relationship differ across …

Objectives: A growing number of prospective clinical trials include economic end points.
Recognizing the variation in methodology and reporting of these studies, the International …

Clinical studies use a wide variety of health status measures to measure health related
quality of life, many of which cannot be used in cost-effectiveness analysis using cost per …