Apoptosis is a process of programmed cell death that serves as a major mechanism for the
precise regulation of cell numbers, and as a defense mechanism to remove unwanted and …

A mammalian cell houses two genomes located separately in the nucleus and mitochondria.
During evolution, communications and adaptations between these two genomes occur …

Apoptosis induced by p53 is firmly established as a central mechanism of tumour
suppression. In addition to its complex functions as a nuclear transcription factor, p53 can …

The role of oncoproteins and tumor suppressor proteins in promoting the malignant
transformation of mammalian cells by affecting properties such as proliferative signalling …

The p53 tumor suppressor plays a central role in dictating cell survival and death as a
cellular sensor for a myriad of stresses including DNA damage, oxidative and nutritional …

During the course of tumorigenesis, cells acquire a number of alterations that contribute to
the acquisition of the malignant phenotype, allowing them to survive and flourish in …

Among the characteristics acquired by many tumour cells is a shift from using oxidative
phosphorylation to using glycolysis for ATP production. Although the nuclear factor (NF)-κB …

In eukaryotes, mitochondrial iron-sulfur cluster (ISC), export and cytosolic iron-sulfur cluster
assembly (CIA) machineries carry out biogenesis of iron-sulfur (Fe-S) clusters, which are …

This study evaluated the dependence of p53 protein expression on the occurrence of dark
neurons (DNs) in the hippocampus of rats during experimental modeling of septoplasty …

Background Nowadays, effects of fine particulate matter (PM 2.5) are well-documented and
related to oxidative stress and pro-inflammatory response. Nevertheless, epidemiological …