The aim of this review is to provide basic information on the electrophysiological changes
during acute ischemia and reperfusion from the level of ion channels up to the level of …

Cardiac K+ channels are membrane-spanning proteins that allow the passive movement of
K+ ions across the cell membrane along its electrochemical gradient. They regulate the …

We have established stably transfected HEK 293 cell lines expressing high levels of
functional human ether-a go-go-related gene (HERG) channels. We used these cells to …

Depolarization of human atrial myocytes activates a transient outward current that rapidly
inactivates, leaving a sustained outward current after continued depolarization. To evaluate …

About 10 distinct potassium channels in the heart are involved in shaping the action
potential. Some of the K+ channels are primarily responsible for early repolarization …

Background Sex hormones are known to exert direct and indirect effects on cardiovascular
function, but their effects on cardiac repolarization have not been elucidated. The …

▪ Abstract The normal electrophysiologic behavior of the heart is determined by ordered
propagation of excitatory stimuli that result in rapid depolarization and slow repolarization …

Two distinct delayed rectifier K+ currents, IKr and IKs, were found recently in ventricular
cells. We formulated these currents theoretically and investigated their roles in action …

Recent advances in molecular biology have had a major impact on our understanding of the
biophysical and molecular properties of ion channels. This review is focused on cardiac …

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS)
characterized by demyelination, with a relative sparing of axons. In MS patients, many …