[HTML][HTML] Sarcopenia–Molecular mechanisms and open questions

P Wiedmer, T Jung, JP Castro, LCD Pomatto… - Ageing research …, 2021 - Elsevier
Sarcopenia represents a muscle-wasting syndrome characterized by progressive and
generalized degenerative loss of skeletal muscle mass, quality, and strength occurring …

The continuum of aging and age-related diseases: common mechanisms but different rates

C Franceschi, P Garagnani, C Morsiani, M Conte… - Frontiers in …, 2018 - frontiersin.org
Geroscience, the new interdisciplinary field that aims to understand the relationship between
aging and chronic age-related diseases (ARDs) and geriatric syndromes (GSs), is based on …

Multifactorial mechanism of sarcopenia and sarcopenic obesity. Role of physical exercise, microbiota and myokines

J Bilski, P Pierzchalski, M Szczepanik, J Bonior… - Cells, 2022 - mdpi.com
Obesity and ageing place a tremendous strain on the global healthcare system. Age-related
sarcopenia is characterized by decreased muscular strength, decreased muscle quantity …

Inflammaging: implications in sarcopenia

E Antuña, C Cachán-Vega, JC Bermejo-Millo… - International journal of …, 2022 - mdpi.com
In a world in which life expectancy is increasing, understanding and promoting healthy
aging becomes a contemporary demand. In the elderly, a sterile, chronic and low-grade …

Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases

C Franceschi, J Campisi - Journals of Gerontology Series A …, 2014 - academic.oup.com
Human aging is characterized by a chronic, low-grade inflammation, and this phenomenon
has been termed as “inflammaging.” Inflammaging is a highly significant risk factor for both …

Sarcopenia: assessment of disease burden and strategies to improve outcomes

I Liguori, G Russo, L Aran, G Bulli, F Curcio… - … interventions in aging, 2018 - Taylor & Francis
Life expectancy is increasing worldwide, with a resultant increase in the elderly population.
Aging is characterized by the progressive loss of skeletal muscle mass and strength–a …

Aging and Parkinson's Disease: Inflammaging, neuroinflammation and biological remodeling as key factors in pathogenesis

V Calabrese, A Santoro, D Monti, R Crupi… - Free Radical Biology …, 2018 - Elsevier
In order to better understand the pathogenesis of Parkinson's Disease (PD) it is important to
consider possible contributory factors inherent to the aging process, as age-related changes …

Myogenic progenitor cells control extracellular matrix production by fibroblasts during skeletal muscle hypertrophy

CS Fry, TJ Kirby, K Kosmac, JJ McCarthy, CA Peterson - Cell stem cell, 2017 - cell.com
Satellite cells, the predominant stem cell population in adult skeletal muscle, are activated in
response to hypertrophic stimuli and give rise to myogenic progenitor cells (MPCs) within …

Clinical relevance of sarcopenia in chronic kidney disease

RN Moorthi, KG Avin - Current opinion in nephrology and …, 2017 - journals.lww.com
Sarcopenia, now with its own International Classification of Diseases, 10th Revision (ICD-
10) code, is of importance clinically and should be accounted for in research studies in …

Role of inflammation in muscle homeostasis and myogenesis

D Costamagna, P Costelli… - Mediators of …, 2015 - Wiley Online Library
Skeletal muscle mass is subject to rapid changes according to growth stimuli inducing both
hypertrophy, through increased protein synthesis, and hyperplasia, activating the myogenic …