Future of digital assays to resolve clinical heterogeneity of single extracellular vesicles

RTT Morales, J Ko - ACS nano, 2022 - ACS Publications
Extracellular vesicles (EVs) are complex lipid membrane vehicles with variable expressions
of molecular cargo, composed of diverse subpopulations that participate in the intercellular …

Advances in extracellular vesicle nanotechnology for precision theranostics

Q Wu, S Fu, H Xiao, J Du, F Cheng, S Wan… - Advanced …, 2023 - Wiley Online Library
Extracellular vesicles (EVs) have increasingly been recognized as important cell surrogates
influencing many pathophysiological processes, including cellular homeostasis, cancer …

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

JA Welsh, DCI Goberdhan, L O'Driscoll… - Journal of …, 2024 - Wiley Online Library
Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of
origin and change the functions and phenotypes of other cells. These features indicate …

L1CAM‐associated extracellular vesicles: A systematic review of nomenclature, sources, separation, and characterization

DE Gomes, KW Witwer - Journal of Extracellular Biology, 2022 - Wiley Online Library
When released into biological fluids like blood or saliva, brain extracellular vesicles (EVs)
might provide a window into otherwise inaccessible tissue, contributing useful biomarkers of …

A beginner's guide to study extracellular vesicles in human blood plasma and serum

R Nieuwland, PRM Siljander - Journal of extracellular vesicles, 2024 - Wiley Online Library
Blood is the most commonly used body fluid for obtaining and studying extracellular vesicles
(EVs). While blood is a standard choice for clinical analysis, using blood as a source of EVs …

Harnessing the therapeutic potential of extracellular vesicles for biomedical applications using multifunctional magnetic nanomaterials

L Yang, KD Patel, C Rathnam, R Thangam, Y Hou… - Small, 2022 - Wiley Online Library
Extracellular vesicles (eg, exosomes) carrying various biomolecules (eg, proteins, lipids,
and nucleic acids) have rapidly emerged as promising platforms for many biomedical …

Biomarker and therapeutic potential of peripheral extracellular vesicles in Alzheimer's disease

C Vandendriessche, D Kapogiannis… - Advanced drug delivery …, 2022 - Elsevier
Extracellular vesicles (EVs) are cell-derived nanoparticles with an important role in
intercellular communication, even across brain barriers. The bidirectional brain-barrier …

The capture of extracellular vesicles endogenously released by xenotransplanted tumours induces an inflammatory reaction in the premetastatic niche

L Blavier, R Nakata, P Neviani… - Journal of …, 2023 - Wiley Online Library
The capture of tumour‐derived extracellular vesicles (TEVs) by cells in the tumour
microenvironment (TME) contributes to metastasis and notably to the formation of the pre …

All-in-One Nanowire Assay System for Capture and Analysis of Extracellular Vesicles from an ex Vivo Brain Tumor Model

K Chattrairat, T Yasui, S Suzuki, A Natsume… - ACS …, 2023 - ACS Publications
Extracellular vesicles (EVs) have promising potential as biomarkers for early cancer
diagnosis. The EVs have been widely studied as biological cargo containing essential …

Brain tissue-derived extracellular vesicles in Alzheimer's disease display altered key protein levels including cell type-specific markers

Y Huang, TAP Driedonks, L Cheng… - Journal of …, 2022 - content.iospress.com
Background: Brain tissue-derived extracellular vesicles (bdEVs) play neurodegenerative
and protective roles, including in Alzheimer's disease (AD). Extracellular vesicles (EVs) may …