Adipose tissue depots can exist in close association with other organs, where they assume
diverse, often non-traditional functions. In stem cell-rich skin, bone marrow, and mammary …

Graves orbitopathy, also known as thyroid eye disease or thyroid-associated orbitopathy, is
visually disabling, cosmetically disfiguring and has a substantial negative impact on a …

This article reviews the mechanisms that lead to the development of Graves'
ophthalmopathy. A central feature in its development is autoimmunity that involves not only T …

Thyroid eye disease (TED) is the most common extra thyroidal manifestation of Graves'
disease (GD). It may also present in those who are hypothyroid or euthyroid. The …

Orbital changes in thyroid orbitopathy (TO) result from de novo adipogenesis, hyaluronan
synthesis, interstitial oedema and enlargement of extraocular muscles. Cellular immunity …

Environmental, genetic, and immune factors are at play in the development of the variable
clinical manifestations of Graves' ophthalmopathy (GO). Among the environmental …

Graves' ophthalmopathy (GO) is an extra-thyroidal complication of Graves' disease (GD;
Graves' hyperthyroidism) characterized by orbital tissue inflammation, expansion …

Abstract Context: The TSH receptor (TSHR) is considered the main target of stimulatory
autoantibodies in the pathogenesis of Graves' ophthalmopathy (GO); however, it has been …

The body's autoimmune process is involved in the development of Graves' disease (GD),
which is manifested by an overactive thyroid gland. In some patients, autoreactive …

Hyaluronan synthase 1 (HAS1) is one of three isoenzymes responsible for cellular
hyaluronan synthesis. Interest in HAS1 has been limited because its role in hyaluronan …