Exposure to hostile conditions initiates responses organized to enhance the probability of
survival. These coordinated responses, known as stress responses, are composed of …

The subject of neuroinflammation is reviewed. In response to psychological stress or certain
physical stressors, an inflammatory process may occur by release of neuropeptides …

The localization of substance P in brain regions that coordinate stress responses and
receive convergent monoaminergic innervation suggested that substance P antagonists …

Substance P (SP) is one of the most abundant peptides in the central nervous system and
has been implicated in a variety of physiological and pathophysiological processes …

Increasing evidence implicates the substance P (SP)/neurokinin-1 receptor system in
anxiety and depression. However, it is not known whether emotional stimulation alters …

Alopecia areata (AA) is an autoimmune dermatological disease with multifactorial etiology
and is characterized by reversible hair loss in patches. AA may be closely related to …

This article provides an overview of the structure and function of substance P signalling
system and its involvement in the cardiovascular regulation. Substance P is an …

This review considers future directions for developing effective drugs for posttraumatic stress
disorder (PTSD). At present, we have embarked upon an empirical approach in which …

The first report demonstrating the therapeutic efficacy of an orally applied neurokinin-1
(NK1) receptor antagonist in depression was published 10 years ago. Although there were …

The regulation of stress-induced vocalisations by central NK1 receptors was investigated
using pharmacological antagonists in guinea-pigs, a species with human-like NK1 …