The pathophysiologies of neurodegenerative diseases, including amyotrophic lateral
sclerosis (ALS), Parkinson's disease (PD), and Alzheimer's disease (AD), are far from being …

Cholesterol is an indispensable component of the cell membrane and plays vital roles in
critical physiological processes. Brain cholesterol accounts for a large portion of total …

Parkinson's disease (PD) is a neurodegenerative disease characterized by a progressive
loss of dopaminergic neurons from the nigrostriatal pathway, formation of Lewy bodies, and …

Lipid peroxidation (LPO) has been shown to induce disturbance of membrane organization
and functional loss and modification of proteins and DNA bases, and it has been implicated …

The role and beneficial effects of antioxidants against various disorders and diseases
induced by oxidative stress have received much attention. Many types of antioxidants with …

Glycerophospholipids represent a common class of lipids critically important for integrity of
cellular membranes. Oxidation of esterified unsaturated fatty acids dramatically changes …

Parkinson disease (PD), the most common neurodegenerative movement disorder, is
associated with selective degeneration of nigrostriatal dopamine neurons. Although the …

In my career I have moved from chemistry to biochemistry to plant science to clinical
chemistry and back again (in a partial way) to plants. This review presents a brief history of …

Parkinson's disease (PD) is the second most progressive neurodegenerative disorder of the
aging population after Alzheimer's disease (AD). Defects in the lysosomal systems and …

Free radicals derived primarily from molecular oxygen have been implicated in a variety of
human disorders including atherosclerosis, cancer, neurodegenerative diseases, and aging …