The papillomavirus E2 proteins are pivotal to the viral life cycle and have well characterized
functions in transcriptional regulation, initiation of DNA replication and partitioning the viral …

Animal and human papillomaviruses (HPVs) replicate persistently in specific types of
stratified epithelia of their host. After the initial infection, the viral genome replicates at low …

Bromodomain protein 4 (Brd4) plays critical roles in development, cancer progression, and
virus-host pathogenesis. To gain mechanistic insight into the various biological functions of …

Over the last two decades, since the initial discovery of human papillomavirus (HPV) type 16
and 18 DNAs in cervical cancers by Dr. Harald zur Hausen (winner of the Nobel Prize in …

Human papillomaviruses (HPV) are a large family of viruses which contain a circular, double-
stranded DNA genome of approximately 8000 base pairs. The viral DNA is chromatinized by …

Abstract The Bromodomain and Extra-terminal (BET) family of proteins were first recognized
as important epigenetic regulators in inflammatory processes; however, there is increasing …

Human papillomaviruses (HPV) are small DNA viruses that contain a compact and non-
redundant genome. HPV, with the help of only few genes, can achieve a complete …

In the last decades, a group of viruses has received great attention due to its relationship
with cancer development and its wide distribution throughout the vertebrates: the …

An essential step in the pathogenesis of human papillomavirus (HPV)–associated cancers is
the dysregulated expression of the viral oncogenes. The papillomavirus E2 protein can …

The TIP60 tumor suppressor is a histone acetyltransferase involved in transcriptional
regulation, checkpoint activation, and p53-directed proapoptotic pathways. We report that …