Mitochondrial dysfunction, cause or consequence in neurodegenerative diseases?

ZP Van Acker, T Leroy, W Annaert - BioEssays, 2025 - Wiley Online Library
Neurodegenerative diseases encompass a spectrum of conditions characterized by the
gradual deterioration of neurons in the central and peripheral nervous system. While their …

[HTML][HTML] Alterations in Lysosomal, Glial and Neurodegenerative Biomarkers in Patients with Sporadic and Genetic Forms of Frontotemporal Dementia

J Hsiao-Nakamoto, CL Chiu, L VandeVrede, R Ravi… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Background Frontotemporal dementia (FTD) is the most common cause of early-onset
dementia with 10–20% of cases caused by mutations in one of three genes: GRN, C9orf72 …

Large-scale CSF proteome profiling identifies biomarkers for accurate diagnosis of Frontotemporal Dementia

YS Hok-A-Hin, L Vermunt, CFW Peeters… - medRxiv, 2024 - pmc.ncbi.nlm.nih.gov
Diagnosis of Frontotemporal dementia (FTD) and the specific underlying neuropathologies
(frontotemporal lobar degeneration; FTLD-Tau and FTLD-TDP) is challenging, and thus fluid …

DNA methylation as a contributor to dysregulation of STX6 and other frontotemporal lobar degeneration genetic risk-associated loci

N Rambarack, K Fodder, M Murthy, C Toomey… - bioRxiv, 2025 - biorxiv.org
Frontotemporal Lobar Degeneration (FTLD) represents a spectrum of clinically, genetically,
and pathologically heterogeneous neurodegenerative disorders characterised by …

Reduction of Sphingomyelinases Associated With Progranulin Deficiency and Frontotemporal Dementia

NR Boyle - 2023 - search.proquest.com
Frontotemporal dementia (FTD) is a leading cause of early-onset dementia and has a
significant socioeconomic burden due to difficulties in diagnosis and delay to diagnosis. FTD …