In managing patients with solid tumors, the value of detecting the status of tumor DNA
mismatch repair function is widely recognized. Mismatch repair protein …

DNA mismatch repair deficiency (MMRd) is associated with a high tumor mutational burden
(TMB) and sensitivity to immune checkpoint blockade (ICB) therapy. Nevertheless, most …

Simple Summary Microsatellite instability (MSI) is a molecular fingerprint for defects in the
mismatch repair system (dMMR) and is associated with higher risks of cancers. MSI/dMMR …

Detecting mutations from single DNA molecules is crucial in many fields but challenging.
Next-generation sequencing (NGS) affords tremendous throughput but cannot directly …

The neuroendocrine carcinoma of the gastrointestinal system (GIS-NEC) is a rare but highly
malignant neoplasm. We analyzed 115 cases using whole-genome/exome sequencing …

For inoperable esophageal adenocarcinoma (EAC), identifying patients likely to benefit from
recently approved immunochemotherapy (ICI+ CTX) treatments remains a key challenge …

A growing number of druggable targets and national initiatives for precision oncology
necessitate broad genomic profiling for many cancer patients. Whole exome sequencing …

Background In gastric cancer (GC) patients, metastatic progression through the lymphatic,
hematogenous, peritoneal, and ovarian routes, is the ultimate cause of death. However, the …

Background Immune checkpoint inhibitors combined with chemotherapy as a neoadjuvant
therapy have been applied to the treatment of esophageal squamous cell carcinoma …

In the evolving molecular treatment landscape of metastatic colorectal cancer (mCRC), the
identification of druggable alterations is pivotal to achieve the best therapeutic opportunity …