Antibiotic resistance mechanisms reported in Gram-negative bacteria are causing a
worldwide health problem. The continuous dissemination of 'multidrug-resistant'(MDR) …

The Tet repressor protein (TetR) regulates transcription of a family of tetracycline (tc)
resistance determinants in Gram‐negative bacteria. The resistance protein TetA, a …

To win the battle against resistant, pathogenic bacteria, novel classes of anti-infectives and
targets are urgently needed. Bacterial uptake, distribution, metabolic and efflux pathways of …

Novel classes of broad-spectrum antibiotics have been extremely difficult to discover, largely
due to the impermeability of the Gram-negative membranes coupled with a poor …

This is a review. Non-electrolytic compounds typically cross cell membranes by passive
diffusion. The rate of permeation is dependent on the chemical properties of the solute and …

First proposed as antimicrobial agents, histones were later recognized for their role in
condensing chromosomes. Histone antimicrobial activity has been reported in innate …

Cell envelope plays a dual role in the life of bacteria by simultaneously protecting it from a
hostile environment and facilitating access to beneficial molecules. At the heart of this ability …

Complexation of tetracycline with dissolved organic matter (DOM) in aqueous solution could
alter the bioavailability of tetracycline to bacteria, thereby alleviating selective pressure for …

Riboswitches reflect a novel concept in gene regulation that is particularly suited for
technological adaptation. Therefore, we characterized thermodynamically the ligand binding …

Integral membrane proteins act as critical cellular components and are important drug
targets. However, difficulties in producing membrane proteins have hampered investigations …