Exercise training is a clinically proven, cost‐effective, primary intervention that delays and in
many cases prevents the health burdens associated with many chronic diseases. However …

The majority of human energy metabolism occurs in skeletal muscle mitochondria
emphasizing the importance of understanding the regulation of myocellular mitochondrial …

Insulin resistance in skeletal muscle is manifested by decreased insulin‐stimulated glucose
uptake and results from impaired insulin signaling and multiple post‐receptor intracellular …

Given their essential function in aerobic metabolism, mitochondria are intuitively of interest
in regard to the pathophysiology of diabetes. Qualitative, quantitative, and functional …

Long-chain fatty acids and lipids serve a wide variety of functions in mammalian
homeostasis, particularly in the formation and dynamic properties of biological membranes …

Exercise training induces mitochondrial biogenesis, but the time course of molecular
sequelae that accompany repetitive training stimuli remains to be determined in human …

The pathophysiology of type 2 diabetes mellitus (DM) is varied and complex. However, the
association of DM with obesity and inactivity indicates an important, and potentially …

Methods Seven sedentary but otherwise healthy individuals (three women) with a mean±SD
age, body mass index, and peak oxygen uptake (VO (2peak)) of 45±5 yr, 27±5 kg· m (-2) …

Low-volume, high-intensity interval training (HIT) increases skeletal muscle mitochondrial
capacity, yet little is known regarding potential mechanisms promoting this adaptive …

Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that
regulate genes involved in energy metabolism and inflammation. For biological activity …