Strategies to therapeutically target the tumor microenvironment (TME) have emerged as a
promising approach for cancer treatment in recent years due to the critical roles of the TME …

In many solid tumor types, tumor-associated macrophages (TAMs) are important
components of the tumor microenvironment (TME). Moreover, TAMs infiltration is strongly …

Infiltration of macrophages in solid tumours is associated with poor prognosis and correlates
with chemotherapy resistance in most cancers. In mouse models of cancer, macrophages …

As an essential innate immune population for maintaining body homeostasis and warding
off foreign pathogens, macrophages display high plasticity and perform diverse supportive …

It has been recently recognized that the tumor microenvironment (TME) is an essential factor
that defines the efficiency of chemotherapy. The local TME, consisting of immune cells with …

Background: The tumor microenvironment (TME) consists of heterogeneous cell
populations, including malignant cells and nonmalignant cells that support tumor …

Rationale: Cancer immunotherapy combining immune checkpoint blockade (ICB) with
chemotherapeutic drugs has provided significant clinical advances. However, such …

Cancer cells resistance to various therapies remains to be a key challenge nowadays. For a
long time, scientists focused on tumor cells themselves for the mechanisms of acquired drug …

Macrophages are specialized cells that control tissue homeostasis. They include non-
resident and tissue-resident macrophage populations which are characterized by the …

Tumor evasion of immune destruction is associated with the production of
immunosuppressive adenosine in the tumor microenvironment (TME). Anticancer therapies …