With the aging population, prevalence of neurodegenerative diseases is increasing, thus
placing a growing burden on individuals and the whole society. However, individual rates of …

Life history theory argues that exposure to early life adversity (ELA) accelerates
development, although existing evidence for this varies. We present a meta-analysis and …

Parenchymal lung disease is the fourth leading cause of death in the United States; among
the top causes, it continues on the rise. Telomeres and telomerase have historically been …

Background Cigarette smoking is a risk factor for ageing-related disease, but its association
with biological ageing, indicated by telomere length, is unclear. Methods We systematically …

To determine the most important drivers of successful ageing at extreme old age, we
combined community-based prospective cohorts: Tokyo Oldest Old Survey on Total Health …

Many psychiatric illnesses are associated with early mortality and with an increased risk of
developing physical diseases that are more typically seen in the elderly. Moreover, certain …

Background: Short telomeres in peripheral blood leukocytes are associated with older age
and age-related diseases. We tested the hypotheses that short telomeres are associated …

Cardiovascular disease (CVD) is the leading cause of death and disability worldwide, and
experiences of psychological trauma have been associated with subsequent CVD onset …

Telomere length (TL) predicts the onset of cellular senescence in vitro but the diagnostic
utility of TL measurement in clinical settings is not fully known. We tested the value of TL …

Telomeres are the protective end caps of chromosomes and shorten with every cell division.
Telomere length has been proposed as a biomarker of biological age and a risk factor for …