Cancer stem cells (CSCs), also known as tumor‐initiating cells (TICs), are suggested to be
responsible for drug resistance and cancer relapse due in part to their ability to self‐renew …

Although we have come a long way in our understanding of the signals that drive cancer
growth, and how these signals can be targeted, effective control of this disease remains a …

Medulloblastoma (MB) comprises a biologically heterogeneous group of embryonal tumours
of the cerebellum. Four subgroups of MB have been described (WNT, sonic hedgehog …

Abstract While N 6-methyladenosine (m6A), the most abundant internal modification in
eukaryotic mRNA, is linked to cell differentiation and tissue development, the biological …

Compelling evidence have demonstrated that bulk tumors can arise from a unique subset of
cells commonly termed “cancer stem cells” that has been proposed to be a strong driving …

SOX2 is a well-characterized pluripotent factor that is essential for stem cell self-renewal,
reprogramming, and homeostasis. The cellular levels of SOX2 are precisely regulated by a …

Oligodendrocytes myelinate axons in the central nervous system and develop from
oligodendrocyte precursor cells (OPCs) that must first migrate extensively during brain and …

Medulloblastoma is a highly malignant paediatric brain tumour, often inflicting devastating
consequences on the developing child. Genomic studies have revealed four distinct …

The differentiation of tumorigenic cancer stem cells into nontumorigenic cancer cells confers
heterogeneity to some cancers beyond that explained by clonal evolution or environmental …

The cancer stem cell (CSC) concept derives from the fact that cancers are dysregulated
tissue clones whose continued propagation is vested in a biologically distinct subset of cells …