Two major functions of the mammalian ovary are the production of germ cells (oocytes),
which allow continuation of the species, and the generation of bioactive molecules, primarily …

Since their original discovery as regulators of follicle-stimulating hormone (FSH) secretion
and erythropoiesis, the TGF-β family members activin and inhibin have been shown to …

Polycystic ovary syndrome (PCOS) affects 5–10% of women of reproductive age, causing a
range of reproductive, metabolic and endocrine defects including anovulation, infertility …

Polycystic ovary syndrome (PCOS) is the most frequent female endocrine disorder, affecting
5%–10% of women, causing infertility due to dysfunctional follicular maturation and …

The recent unraveling of structures of genes for the gonadotropin subunits and gonadotropin
receptors has provided reproductive endocrinologists with new tools to study normal and …

Testosterone and follicle-stimulating hormone (FSH) are required to obtain full reproductive
potential. In the testis, somatic Sertoli cells transduce signals from testosterone and FSH into …

Spermatogenesis in adult mammals is highly organized, with the goal being continual sperm
production. Vertebrate testes are arranged into recurring cellular associations that vary with …

BACKGROUND The significance of the high variation in numbers of follicles produced
during reproductive cycles in humans and cattle is unknown. METHODS We selected beef …

The key component regulating vertebrate puberty and sexual maturation is the endocrine
system primarily effectuated along the brain–pituitary–gonad (BPG) axis. By far most …

Follicle-stimulating hormone (FSH) plays fundamental roles in male and female fertility. FSH
is a heterodimeric glycoprotein expressed by gonadotrophs in the anterior pituitary. The …