Cancer accounts for numerous deaths each year, and it is one of the most common causes
of death worldwide, despite many breakthroughs in the discovery of novel anticancer …

The indole scaffold is found in a wide range of bioactive heterocycles and natural products.
Moreover, the indole moiety is considered as the active principle in several alkaloids such …

Tubulin dynamics is a promising target for new chemotherapeutic agents. The colchicine
binding site is one of the most important pockets for potential tubulin polymerization …

Transporters in proximal renal tubules contribute to the disposition of numerous drugs.
Furthermore, the molecular mechanisms of tubular secretion have been progressively …

Microtubules are the basic components of cell structure, which take part in a wide number of
pivotal cellular functions. Drugs that are able to modulate the microtubule assembly either by …

The unique characteristics of the tumor vasculature offer the possibility to selectively target
tumor growth and vascularization using tubulin-destabilizing agents. Evidence accumulated …

Introduction: Coumarins are a group of plant-derived polyphenolic compounds. They belong
to the benzopyrones family and possess a wide variety of cytoprotective and modulatory …

Epigenetic enzymes histone deacetylases (HDACs) are clinically validated anticancer drug
targets which have been studied intensively in the past few decades. Although several drugs …

Hypoxia induced drug resistance is a major obstacle in the development of effective cancer
therapy. Our previous study revealed that hypoxia‐inducible factor‐1 (HIF‐1), the major …

Interstitial flow in and around tumor tissue affects the mechanical microenvironment to
modulate tumor cell growth and metastasis. We investigated the roles of flow-induced shear …