Coordinated transcription factor networks have emerged as the master regulatory
mechanisms of stem cell pluripotency and differentiation. Many stem cell-specific …

Stem cells (SC) are able to self-renew and to differentiate into many types of committed cells,
making SCs interesting for cellular therapy. However, the pool of SCs in vivo and in vitro …

The Pou domain containing transcription factor Oct4 is a well-established regulator of
pluripotency in the inner cell mass of the mammalian blastocyst as well as in embryonic …

Human induced pluripotent stem cells (hiPSCs) generated by de-differentiation of adult
somatic cells offer potential solutions for the ethical issues surrounding human embryonic …

Abstract Reduced expression 1 (REX1) is a widely used pluripotency marker, but little is
known about its roles in pluripotency. Here, we show that REX1 is functionally important in …

Abstract Octamer 4 (Oct4), a member of the POU family of transcription factors, plays a key
role in the maintenance of pluripotency and proliferation potential of embryonic stem cells …

ZFP42 zinc finger protein (REX1), a pluripotency marker in mouse pluripotent stem cells, has
been identified as a tumor suppressor in several human cancers. However, the function of …

Pluripotency is a unique biological state that allows cells to differentiate into any tissue type.
Here we describe a candidate pluripotency factor, Ronin, that possesses a THAP domain …

Urodeles and fetal mammals are capable of impressive epimorphic regeneration in a variety
of tissues, whereas the typical default response to injury in adult mammals consists of …

Biological scaffolds composed of naturally occurring extracellular matrix (ECM) have been
utilized as templates for the constructive remodelling of numerous tissues in preclinical …