[HTML][HTML] The central role of IL-33/IL-1RL1 pathway in asthma: from pathogenesis to intervention
AKS Jayalatha, L Hesse, ME Ketelaar… - Pharmacology & …, 2021 - Elsevier
Abstract Interleukin-33 (IL-33), a member of the IL-1 family, and its cognate receptor,
Interleukin-1 receptor like-1 (IL-1RL1 or ST2), are susceptibility genes for childhood asthma …
Interleukin-1 receptor like-1 (IL-1RL1 or ST2), are susceptibility genes for childhood asthma …
[HTML][HTML] GATA-3 function in innate and adaptive immunity
I Tindemans, N Serafini, JP Di Santo, RW Hendriks - Immunity, 2014 - cell.com
The zinc-finger transcription factor GATA-3 has received much attention as a master
regulator of T helper 2 (Th2) cell differentiation, during which it controls interleukin-4 (IL-4) …
regulator of T helper 2 (Th2) cell differentiation, during which it controls interleukin-4 (IL-4) …
Cell type–specific DNA methylation at intragenic CpG islands in the immune system
Human and mouse genomes contain a similar number of CpG islands (CGIs), which are
discrete CpG-rich DNA sequences associated with transcription start sites. In both …
discrete CpG-rich DNA sequences associated with transcription start sites. In both …
GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells
SY Pai, ML Truitt, IC Ho - Proceedings of the National …, 2004 - National Acad Sciences
T helper type 2 (Th2) cells secrete IL-4, IL-5, IL-10, and IL-13 and mediate allergic and
asthmatic disease. GATA-3 is a Th2-specific transcription factor that appears in …
asthmatic disease. GATA-3 is a Th2-specific transcription factor that appears in …
GATA3-driven TH2 responses inhibit TGF-β1–induced FOXP3 expression and the formation of regulatory T cells
Transcription factors act in concert to induce lineage commitment towards Th1, Th2, or T
regulatory (Treg) cells, and their counter-regulatory mechanisms were shown to be critical …
regulatory (Treg) cells, and their counter-regulatory mechanisms were shown to be critical …
Molecular genetics of T cell development
EV Rothenberg, T Taghon - Annu. Rev. Immunol., 2005 - annualreviews.org
▪ Abstract T cell development is guided by a complex set of transcription factors that act
recursively, in different combinations, at each of the developmental choice points from T …
recursively, in different combinations, at each of the developmental choice points from T …
From the cradle to the grave: activities of GATA‐3 throughout T‐cell development and differentiation
GATA family transcription factors play multiple vital roles in hematopoiesis in many cell
lineages, and in particular, T cells require GATA‐3 for execution of several developmental …
lineages, and in particular, T cells require GATA‐3 for execution of several developmental …
PPAR-γ promotes type 2 immune responses in allergy and nematode infection
A hallmark of immunity to worm infections and many allergies is a strong type 2 immune
response. This is characterized by the production of cytokines interleukin-5 (IL-5) and IL-13 …
response. This is characterized by the production of cytokines interleukin-5 (IL-5) and IL-13 …
GATA-3 directly remodels the IL-10 locus independently of IL-4 in CD4+ T cells
J Shoemaker, M Saraiva, A O'Garra - The Journal of Immunology, 2006 - journals.aai.org
IL-10 is a major regulator in inflammatory responses. Although various transcription factors
were defined to enhance IL-10, the molecular mechanism for the initiation of Il-10 …
were defined to enhance IL-10, the molecular mechanism for the initiation of Il-10 …
IFN-γ: recent advances in understanding regulation of expression, biological functions, and clinical applications
HA Young, JH Bream - Interferon: The 50th Anniversary, 2007 - Springer
Abstract Interferon-gamma (IFN-γ) is a key immunoregulatory protein that plays a major role
in the host innate and adaptive immune response. Also known as type II interferon, IFN-γ is a …
in the host innate and adaptive immune response. Also known as type II interferon, IFN-γ is a …