Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …

A large body of preclinical and clinical data shows that the central melanocortin system is a
promising therapeutic target for treating various metabolic disorders such as obesity and …

The state of somatic energy stores in metazoans is communicated to the brain, which
regulates key aspects of behaviour, growth, nutrient partitioning and development. The …

Phthalate esters (PAEs) are a group of ubiquitous organic environmental contaminants.
Engineered ferromanganese-bearing sludge-derived biochar (SDB), synthesized using one …

The hypothalamic melanocortin system is critically involved in sensing stored energy and
communicating this information throughout the brain, including to brain regions controlling …

This review considers three aspects of recent work on the role of KNDy neurons in GnRH
pulse generation in ruminants. First, work on basic mechanisms of pulse generation …

Glucose homeostasis can be improved after bariatric surgery, which alters bile flow and
stimulates gut hormone secretion, particularly FGF15/19. FGFR1 expression in AGRP …

Here we describe the development and application of miniature integrated microscopes
(miniscopes) paired with microendoscopes that allow for the visualization and manipulation …

Alpha-melanocyte stimulating hormone (α-MSH) and its receptor, melanocortin 1 receptor
(MC1R), have been proposed as potential target for anti-cancer strategies in melanoma …

Melanocortin receptors have emerged as important targets with a very unusual versatility, as
their widespread distribution on multiple tissues (eg skin, adrenal glands, brain, immune …