Abnormalities of the endosomal–lysosomal network (ELN) are a signature feature of
Alzheimer's disease (AD). These include the earliest known cytopathology that is specific to …

Glial cell-derived neurotrophic factor (GDNF), and the neurotrophin nerve growth factor
(NGF) and brain-derived neurotrophic factor (BDNF) are important for the survival …

It has been well established that neuronal loss within the cholinergic nucleus basalis of
Meynert (nbM) correlates with cognitive decline in dementing disorders such as Alzheimer's …

A major feature of Alzheimer's disease (AD) is the loss of noradrenergic locus coeruleus
(LC) projection neurons that mediate attention, memory, and arousal. However, the extent to …

Alzheimer's disease (AD) is characterized by a progressive phenotypic downregulation of
markers within cholinergic basal forebrain (CBF) neurons, frank CBF cell loss and reduced …

The neurotrophins are growth factors that play critical roles in the development,
maintenance, survival, and death of the nervous system. The signal transducing systems …

In Alzheimer's disease (AD), loss of cortical and hippocampal choline acetyltransferase
(ChAT) activity has been correlated with dementia severity and disease duration, and it …

Huperzine A (HupA), a novel alkaloid isolated from the Chinese herb Huperzia serrata, is a
potent, highly specific and reversible inhibitor of acetylcholinesterase (AChE). Compared …

Recent evidence suggests that neurotrophic factors that promote the survival or
differentiation of developing neurons may also protect mature neurons from neuronal …

The basal forebrain cholinergic neurons (BFCN) provide the primary source of cholinergic
innervation of the human cerebral cortex. They are involved in the cognitive processes of …