Toward a pathophysiology inspired treatment of VEXAS syndrome

M Heiblig, BA Patel, EM Groarke, E Bourbon… - Seminars in …, 2021 - Elsevier
VEXAS syndrome has an unmet need for therapeutic interventions. Even if few data exist
regarding the treatment of this newly described syndrome, different options can be proposed …

Approach to the diagnosis of aplastic anemia

AE DeZern, JE Churpek - Blood Advances, 2021 - ashpublications.org
Establishing a diagnosis of aplastic anemia (AA) can be challenging, but it is absolutely
critical to appropriate management, especially differentiating between acquired and …

Post-transplantation cyclophosphamide-based graft-versus-host disease prophylaxis

J Bolaños-Meade, M Hamadani, J Wu… - … England Journal of …, 2023 - Mass Medical Soc
Background In patients undergoing allogeneic hematopoietic stem-cell transplantation
(HSCT), a calcineurin inhibitor plus methotrexate has been a standard prophylaxis against …

Indications for haematopoietic cell transplantation for haematological diseases, solid tumours and immune disorders: current practice in Europe, 2022

JA Snowden, I Sánchez-Ortega… - Bone marrow …, 2022 - nature.com
For over two decades, the EBMT has updated recommendations on indications for
haematopoietic cell transplantation (HCT) practice based on clinical and scientific …

Alternative donor BMT with posttransplant cyclophosphamide as initial therapy for acquired severe aplastic anemia

AE DeZern, M Zahurak, HJ Symons… - Blood, The Journal …, 2023 - ashpublications.org
Severe aplastic anemia (SAA) is a marrow failure disorder with high morbidity and mortality.
It is treated with bone marrow transplantation (BMT) for those with fully matched donors, or …

[PDF][PDF] 单倍型供者造血干细胞移植治疗重型再生障碍性贫血的单中心研究

杜志丛, 赵艳丽, 曹星玉, 刘德琰, 熊敏… - 临床血液学 …, 2023 - lcxyen.whuhzzs.com
目的: 探讨单倍型造血干细胞移植(haplo-HSCT) 治疗重型再生障碍性贫血(SAA) 的疗效. 方法:
回顾性分析2012 年9 月—2019 年11 月接受HID-HSCT 的120 例儿童和成人SAA …

Post-transplant cyclophosphamide–based graft-versus-host disease prophylaxis attenuates disparity in outcomes between use of matched or mismatched unrelated …

BC Shaffer, M Gooptu, TE DeFor, M Maiers… - Journal of Clinical …, 2024 - ascopubs.org
PURPOSE Access to allogeneic hematopoietic cell transplantation (HCT) remains limited
among persons of non-European ancestry if human leukocyte antigen (HLA) matching is …

Haploidentical bone marrow transplantation in patients with relapsed or refractory severe aplastic anaemia in the USA (BMT CTN 1502): a multicentre, single-arm …

AE DeZern, M Eapen, J Wu, JA Talano… - The Lancet …, 2022 - thelancet.com
Background Relapsed severe aplastic anaemia is a marrow failure disorder with high
morbidity and mortality. It is often treated with bone marrow transplantation at relapse post …

How I prevent GVHD in high-risk patients: posttransplant cyclophosphamide and beyond

J Rimando, SR McCurdy, L Luznik - Blood, 2023 - ashpublications.org
Advances in conditioning, graft-versus-host disease (GVHD) prophylaxis and antimicrobial
prophylaxis have improved the safety of allogeneic hematopoietic cell transplantation (HCT) …

Acquired severe aplastic anaemia: how medical therapy evolved in the 20th and 21st centuries

P Scheinberg - British Journal of Haematology, 2021 - Wiley Online Library
The progress in aplastic anaemia (AA) management is one of success. Once an obscure
entity resulting in death in most affected can now be successfully treated with either …