Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …

Cyclodextrins are widely used excipients, composed of glucopyranose units with a cyclic
structure. One of their most important properties, is that their inner cavity is hydrophobic …

Multidrug resistance (MDR) is a pathophysiological phenomenon employed by cancer cells
which limits the prolonged and effective use of chemotherapeutic agents. MDR is primarily …

Several β-cyclodextrin (β-CD) derivatives have been synthesized recently to improve the
physicochemical properties and inclusion capacities of the parent molecule, however, there …

Cancer, a disease of unknown origin is the second most common reason of death worldwide
after heart attacks and therefore is a major threat to human beings. Currently, chemotherapy …

Stealth active targeting nanoparticles (NPs) usually include two types of ligand sites: ligand
anchored on distal ends of the polyethylene glycol (PEG) and ligand buried under pegylated …

The use of oral anticancer drugs has increased during the last decade, because of patient
preference, lower costs, proven efficacy, lack of infusion-related inconveniences, and the …

The aim of this work was to study the oral bioavailability in rats of paclitaxel (PTX) when
encapsulated as a complex with cyclodextrins in poly (anhydride) nanoparticles (NP). For …

The aim of this work was to study the effect of the combination between 2-hydroxypropyl-β-
cyclodextrin (HPCD) and bioadhesive nanoparticles on the encapsulation and intestinal …

Biological barriers are the main defense systems of the homeostasis of the organism and
protected organs. The blood–brain barrier (BBB), formed by the endothelial cells of brain …