Many studies have shown that the efficacy and risk of side effects of drug treatment is
influenced by genetic variants. Evidence based guidelines are essential for implementing …

Allergists and clinical immunologists around the world are increasingly faced with the task of
addressing drug allergy and hypersensitivity due to the increase in drug reactions …

Resolving conflict of interest The Joint Task Force on Practice Parameters (JTFPP) is
committed to ensuring that all guidelines are based on the best scientific evidence at the …

Statins reduce cholesterol, prevent cardiovascular disease, and are among the most
commonly prescribed medications in the world. Statin‐associated musculoskeletal …

Nonsteroidal anti‐inflammatory drugs (NSAIDs) are among the most commonly used
analgesics due to their lack of addictive potential. However, NSAIDs have the potential to …

The implementation of pharmacogenomic (PGx) testing in psychiatry remains modest, in part
due to divergent perceptions of the quality and completeness of the evidence base and …

Introduction Reporting and sharing pharmacogenetic test results across clinical laboratories
and electronic health records is a crucial step toward the implementation of clinical …

Phenytoin is an antiepileptic drug with a narrow therapeutic index and large interpatient
pharmacokinetic variability, partly due to genetic variation in CYP2C9. Furthermore, the …

Adverse drug reactions (ADRs) are common in older adults, with falls, orthostatic
hypotension, delirium, renal failure, gastrointestinal and intracranial bleeding being amongst …

The variant allele HLA‐B* 15: 02 is strongly associated with greater risk of Stevens–Johnson
syndrome (SJS) and toxic epidermal necrolysis (TEN) in patients treated with …