Liver disease accounts for two million deaths annually and is responsible for 4% of all
deaths (1 out of every 25 deaths worldwide); approximately two-thirds of all liver-related …

Acute-on-Chronic Liver Failure Acute decompensation in patients with chronic liver disease
is called acute-on-chronic liver failure. Usually, systemic inflammation from infection or an …

The term acute-on-chronic liver failure (ACLF) defines an abrupt and life-threatening
worsening of clinical conditions in patients with cirrhosis or chronic liver disease. In recent …

Acute-on-chronic liver failure (ACLF), which was described relatively recently (2013), is a
severe form of acutely decompensated cirrhosis characterised by the existence of organ …

Background and Aims Patients with cirrhosis are at increased risk of postoperative mortality.
Currently available tools to predict postoperative risk are suboptimally calibrated and do not …

There are different operating definitions for acute-on-chronic liver failure (ACLF) in different
geographic regions. Consortia in Western countries have developed definitions that apply to …

Macrophages facilitate essential homeostatic functions eg, endocytosis, phagocytosis, and
signaling during inflammation, and express a variety of scavenger receptors including …

Background & Aims It is unclear whether the model for end-stage liver disease-sodium
(MELD-Na) score captures the clinical severity of acute-on-chronic liver failure (ACLF). We …

Background and Aims Tolerance is transplantation's holy grail, as it denotes allograft health
without immunosuppression and its toxicities. Our aim was to determine, among stable long …

Background & Aims The impact of proton pump inhibitory (PPI) medications on adverse
outcomes in cirrhosis remains controversial. We aimed to evaluate the association between …