Physiology of the read–write genome
JA Shapiro - The Journal of Physiology, 2014 - Wiley Online Library
Discoveries in cytogenetics, molecular biology, and genomics have revealed that genome
change is an active cell‐mediated physiological process. This is distinctly at variance with …
change is an active cell‐mediated physiological process. This is distinctly at variance with …
Design and synthesis of piperine-based photoaffinity probes for revealing potential targets of piperine in neurological disease
L Shen, Y Yang, L Lu, J Huang, W He, C Zhao… - Chemical …, 2025 - pubs.rsc.org
Piperine (PIP) has attracted extensive attention due to its diverse biological activities. In this
study, we developed two photoaffinity probes PIP-1 and PIP-2, which are biologically safe …
study, we developed two photoaffinity probes PIP-1 and PIP-2, which are biologically safe …
Characterization of proliferating cell nuclear antigen (PCNA) from pathogenic yeast Candida albicans and its functional analyses in S. Cerevisiae
Background Proliferating cell nuclear antigen (PCNA/POL30) an essential protein forms a
homotrimeric ring encircling dsDNA and serves as a molecular scaffold to recruit various …
homotrimeric ring encircling dsDNA and serves as a molecular scaffold to recruit various …
A fluorescent bimolecular complementation screen reveals MAF1, RNF7 and SETD3 as PCNA-associated proteins in human cells
SE Cooper, E Hodimont, CM Green - Cell Cycle, 2015 - Taylor & Francis
The proliferating cell nuclear antigen (PCNA) is a conserved component of DNA replication
factories, and interactions with PCNA mediate the recruitment of many essential DNA …
factories, and interactions with PCNA mediate the recruitment of many essential DNA …
Geminivirus replication protein impairs SUMO conjugation of proliferating cellular nuclear antigen at two acceptor sites
M Arroyo-Mateos, B Sabarit, F Maio… - Journal of …, 2018 - Am Soc Microbiol
Geminiviruses are DNA viruses that replicate in nuclei of infected plant cells using the plant
DNA replication machinery, including PCNA (proliferating cellular nuclear antigen), a …
DNA replication machinery, including PCNA (proliferating cellular nuclear antigen), a …
Mechanism of homologous recombination
M Sebesta, L Krejci - … , and Repair: Molecular Mechanisms and Pathology, 2016 - Springer
Homologous recombination (HR) maintains genome stability by repairing DNA double-
strand breaks and gaps and restarting replication forks. It is an error-free pathway that uses …
strand breaks and gaps and restarting replication forks. It is an error-free pathway that uses …
Mutations at the subunit interface of yeast proliferating cell nuclear antigen reveal a versatile regulatory domain
M Halmai, O Frittmann, Z Szabo, A Daraba, VK Gali… - PLoS …, 2016 - journals.plos.org
Proliferating cell nuclear antigen (PCNA) plays a key role in many cellular processes and
due to that it interacts with a plethora of proteins. The main interacting surfaces of …
due to that it interacts with a plethora of proteins. The main interacting surfaces of …
A residue of motif III positions the helicase domains of motor subunit HsdR in restriction-modification enzyme EcoR124I
D Sinha, V Bialevich, K Shamayeva… - Journal of Molecular …, 2018 - Springer
Type I restriction-modification enzymes differ significantly from the type II enzymes
commonly used as molecular biology reagents. On hemi-methylated DNAs type I enzymes …
commonly used as molecular biology reagents. On hemi-methylated DNAs type I enzymes …
Investigating the role of the Rad51 regulation by Srs2 and Rad54 during DNA replication and repair
T Andriuskevicius - 2022 - era.ed.ac.uk
DNA carries the information necessary for the continuity of life. However, its integrity is
constantly threatened by genotoxic stress exerted by various exogenous and endogenous …
constantly threatened by genotoxic stress exerted by various exogenous and endogenous …
COMPUTATIONAL AND BIOCHEMICAL APPROACHES FOR THE PREDICTION AND CHARACTERIZATION OF DNA REPAIR SYNERGY IN CANCERS
JM Gast - 2021 - hammer.purdue.edu
This thesis Cancer is the second leading cause of death in the modern world, only trailing
congestive heart disease. Many factors contribute to the mortality rate, including the diversity …
congestive heart disease. Many factors contribute to the mortality rate, including the diversity …