Memory in ion channel kinetics

MP Silva, CG Rodrigues, WA Varanda, RA Nogueira - Acta Biotheoretica, 2021 - Springer
Ion channels are transport proteins present in the lipid bilayers of biological membranes.
They are involved in many physiological processes, such as the generation of nerve …

Adaptive-step methods for Markov-based membrane models

JM Gomes, RS Oliveira, M Lobosco… - … in Nonlinear Science …, 2020 - Elsevier
This work presents new adaptive time-step schemes based on the Uniformization method for
solving stiff electrophysiology models of excitable cells. Uniformization is a numerical …

A memory optimization method combined with adaptive time-step method for cardiac cell simulation based on multi-GPU

CH Luo, H Ye, X Chen - Medical & Biological Engineering & Computing, 2020 - Springer
Cardiac electrophysiological simulation is a very complex computational process, which can
be run on graphics processing unit (GPU) to save computational cost greatly. The use of …

Combination of “generalized Trotter operator splitting” and “quadratic adaptive algorithm” method for tradeoff among speedup, stability, and accuracy in the Markov …

XJ Chen, CH Luo, MH Chen - Medical & Biological Engineering & …, 2020 - Springer
The fast hybrid operator splitting (HOS) and stable uniformization (UNI) methods have been
proposed to save computation cost and enhance stability for Markov chain model in cardiac …

A Novel Triple-gate Model for Mechanosensitive Ion Channel Piezo1

Y Zhang, Q Zou - 2022 10th International Conference on …, 2022 - ieeexplore.ieee.org
In this paper, we have developed a Hodgkin-Huxley (HH)-type triple-gate model for
mechanosensitive ion channel Piezo1. The model can simulate currents elicited at an …

[PDF][PDF] Combination of multi-variable quadratic adaptive algorithm and hybrid operator splitting method for stability against acceleration in the Markov model of sodium …

CH Luo, XJ Chen, MH Chen… - Mathematical Biosciences …, 2020 - aimspress.com
Markovian model is widely used to study cardiac electrophysiology and drug screening. Due
to the stiffness of Markov model for single-cell simulation, it is prone to induce instability by …

[PDF][PDF] An Adaptive Time-Step Method for Cardiac Cell Simulation based on Multi-GPU

H Ye, CH Luo, X Chen - clausiuspress.com
Cardiac electrophysiological simulation is a very complex computational process. Running
on Graphics processing unit (GPU) is an effective method for cardiac electrophysiological …