Brain penetrating peptides and peptide–drug conjugates to overcome the blood–brain barrier and target CNS diseases

X Zhou, QR Smith, X Liu - Wiley Interdisciplinary Reviews …, 2021 - Wiley Online Library
Nearly one in six people worldwide suffer from disorders of the central nervous system
(CNS). There is an urgent need for effective strategies to improve the success rates in CNS …

Cell-penetrating peptides and antimicrobial peptides: how different are they?

ST Henriques, MN Melo… - Biochemical Journal, 2006 - portlandpress.com
Some cationic peptides, referred to as CPPs (cell-penetrating peptides), have the ability to
translocate across biological membranes in a non-disruptive way and to overcome the …

Persistence and recovery of ZIF-8 and ZIF-67 phytotoxicity

X Zhang, X Hu, H Wu, L Mu - Environmental Science & …, 2021 - ACS Publications
Zeolitic imidazolate frameworks (ZIFs) have been developed quickly and have attracted
considerable attention for use in the detection and removal of various pollutants …

Peptides as pharmacological carriers to the brain: promises, shortcomings and challenges

S Parrasia, I Szabò, M Zoratti… - Molecular …, 2022 - ACS Publications
Central nervous system (CNS) diseases are among the most difficult to treat, mainly
because the vast majority of the drugs fail to cross the blood-brain barrier (BBB) or to reach …

Thermodynamic studies and binding mechanisms of cell-penetrating peptides with lipids and glycosaminoglycans

A Ziegler - Advanced drug delivery reviews, 2008 - Elsevier
Cell-penetrating peptides (CPPs) traverse the membrane of biological cells at low
micromolar concentrations and are able to take various cargo molecules along with. Despite …

Temperature-, concentration- and cholesterol-dependent translocation of L- and D-octa-arginine across the plasma and nuclear membrane of CD34+ leukaemia …

MM Fretz, NA Penning, S Al-Taei, S Futaki… - Biochemical …, 2007 - portlandpress.com
Delineating the mechanisms by which cell-penetrating peptides, such as HIV-Tat peptide,
oligoarginines and penetratin, gain access to cells has recently received intense scrutiny …

Unveiling the mechanism of uptake and sub-cellular distribution of cerium oxide nanoparticles

S Singh, A Kumar, A Karakoti, S Seal, WT Self - Molecular BioSystems, 2010 - pubs.rsc.org
Cerium oxide nanoparticles (CNPs) have been recently studied for their potent superoxide
scavenging properties in both cell and animal model systems. Data from these model …

Bovine serum albumin decorated gold nanoclusters: A fluorescence-based nanoprobe for detection of intracellular hydrogen peroxide

V Jain, S Bhagat, S Singh - Sensors and Actuators B: Chemical, 2021 - Elsevier
Gold nanoclusters are well studied due to their facile synthesis, biocompatibility, limited
photobleaching, and bright fluorescence properties. Monitoring the reactive oxygen species …

[图书][B] Handbook of cell-penetrating peptides

U Langel - 2006 - taylorfrancis.com
Since the first Handbook of Cell-Penetrating Peptides was prepared in 2001, the wealth of
new information on the use of these peptides as transport systems has in fact served to …

Cyclodextrins, blood–brain barrier, and treatment of neurological diseases

M Vecsernyés, F Fenyvesi, I Bácskay, MA Deli… - Archives of medical …, 2014 - Elsevier
Biological barriers are the main defense systems of the homeostasis of the organism and
protected organs. The blood–brain barrier (BBB), formed by the endothelial cells of brain …