Immune-mediated approaches against COVID-19
HF Florindo, R Kleiner, D Vaskovich-Koubi… - Nature …, 2020 - nature.com
Abstract The coronavirus disease-19 (COVID-19) is caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). The long incubation period of this new virus, which …
syndrome coronavirus 2 (SARS-CoV-2). The long incubation period of this new virus, which …
Recent review of COVID-19 management: Diagnosis, treatment and vaccination
The idiopathic Coronavirus disease 2019 (COVID-19) pandemic outbreak caused by the
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has reached global …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has reached global …
Coronavirus susceptibility to the antiviral remdesivir (GS-5734) is mediated by the viral polymerase and the proofreading exoribonuclease
ML Agostini, EL Andres, AC Sims, RL Graham… - MBio, 2018 - Am Soc Microbiol
Emerging coronaviruses (CoVs) cause severe disease in humans, but no approved
therapeutics are available. The CoV nsp14 exoribonuclease (ExoN) has complicated …
therapeutics are available. The CoV nsp14 exoribonuclease (ExoN) has complicated …
A review of potential suggested drugs for coronavirus disease (COVID-19) treatment
The latest pandemic, coronavirus disease-2019 (COVID-19), is associated with high
prevalence and easy transmission, which is expanding globally with no conventional …
prevalence and easy transmission, which is expanding globally with no conventional …
SARS-CoV-2 RNA-dependent RNA polymerase as a therapeutic target for COVID-19
ABSTRACT Introduction: The current SARS-CoV-2 pandemic urgently demands for both
prevention and treatment strategies. RNA-dependent RNA-polymerase (RdRp), which has …
prevention and treatment strategies. RNA-dependent RNA-polymerase (RdRp), which has …
[HTML][HTML] Nanomaterials designed for antiviral drug delivery transport across biological barriers
Viral infections are a major global health problem, representing a significant cause of
mortality with an unfavorable continuously amplified socio-economic impact. The increased …
mortality with an unfavorable continuously amplified socio-economic impact. The increased …
Nucleoside analogues for the treatment of coronavirus infections
AJ Pruijssers, MR Denison - Current opinion in virology, 2019 - Elsevier
Highlights•Coronaviruses (CoV) represent current and future risk for pandemic zoonotic
infections.•Nucleoside analogues are highly active across multiple virus families.•CoVs …
infections.•Nucleoside analogues are highly active across multiple virus families.•CoVs …
Potential therapeutic targets for combating SARS-CoV-2: Drug repurposing, clinical trials and recent advancements
A Pandey, AN Nikam, AB Shreya, SP Mutalik… - Life sciences, 2020 - Elsevier
The present pandemic of SARS-CoV-2 has been a tough task for the whole world to deal
with. With the absence of specific drugs or vaccines against SARS-CoV-2, the situation is …
with. With the absence of specific drugs or vaccines against SARS-CoV-2, the situation is …
[HTML][HTML] A cell-based assay to discover inhibitors of SARS-CoV-2 RNA dependent RNA polymerase
J Zhao, SS Guo, D Yi, Q Li, L Ma, Y Zhang, J Wang… - Antiviral research, 2021 - Elsevier
Antiviral therapeutics is one effective avenue to control and end this devastating COVID-19
pandemic. The viral RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 has been …
pandemic. The viral RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 has been …
Nucleoside analogs and nucleoside precursors as drugs in the fight against SARS-CoV-2 and other coronaviruses
Coronaviruses (CoVs) are positive-sense RNA enveloped viruses, members of the family
Coronaviridae, that cause infections in a broad range of mammals including humans …
Coronaviridae, that cause infections in a broad range of mammals including humans …