Natural killer (NK) cells can swiftly kill multiple adjacent cells if these show surface markers
associated with oncogenic transformation. This property, which is unique among immune …

Immunotherapy with checkpoint blockade induces rapid and durable immune control of
cancer in some patients and has driven a monumental shift in cancer treatment. Neoantigen …

Hepatocellular carcinoma (HCC) has a high prevalence and mortality rate worldwide.
Sorafenib monotherapy has been the standard of first-line treatment for advanced HCC for a …

Advances in immunotherapy have led to durable and long‐term benefits in a subset of
patients across a number of solid tumor types. Understanding of the subsets of patients that …

Antigen-specific CD8+ T cells in chronic viral infections and tumors functionally deteriorate,
a process known as exhaustion. Exhausted T cells are sustained by precursors of exhausted …

Immune 'checkpoint'inhibitors can increase the activity of tumor-resident cytotoxic
lymphocytes and have revolutionized cancer treatment. Current therapies block inhibitory …

The transforming growth factor-β (TGFβ) family are a large group of evolutionarily conserved
cytokines whose signalling modulates cell fate decision-making across varying cellular …

Coatomer complex I (COPI) mediates retrograde vesicular trafficking from Golgi to the
endoplasmic reticulum (ER) and within Golgi compartments. Deficiency in subunit alpha …

Natural killer (NK) cells display a unique inherent ability to identify and eliminate virus-
infected cells and tumor cells. They are particularly powerful for elimination of hematological …

The liver is a major metastatic target organ, and little is known about the role of immunity in
controlling hepatic metastases. Here, we discovered that the concerted and nonredundant …