Progression of continuous downstream processing of monoclonal antibodies: Current trends and challenges

B Somasundaram, K Pleitt, E Shave… - Biotechnology and …, 2018 - Wiley Online Library
Rapid advances in intensifying upstream processes for biologics production have left
downstream processing as a bottleneck in the manufacturing scheme. Biomanufacturers are …

Continuous counter‐current chromatography for capture and polishing steps in biopharmaceutical production

F Steinebach, T Müller‐Späth… - Biotechnology …, 2016 - Wiley Online Library
The economic advantages of continuous processing of biopharmaceuticals, which include
smaller equipment and faster, efficient processes, have increased interest in this technology …

Design and operation of a continuous integrated monoclonal antibody production process

F Steinebach, N Ulmer, M Wolf, L Decker… - Biotechnology …, 2017 - Wiley Online Library
The realization of an end‐to‐end integrated continuous lab‐scale process for monoclonal
antibody manufacturing is described. For this, a continuous cultivation with filter‐based cell …

Matching the Decay Half-Life with the Biological Half-Life: ImmunoPET Imaging with 44Sc-Labeled Cetuximab Fab Fragment

R Chakravarty, S Goel, HF Valdovinos… - Bioconjugate …, 2014 - ACS Publications
Scandium-44 (t 1/2= 3.9 h) is a relatively new radioisotope of potential interest for use in
clinical positron emission tomography (PET). Herein, we report, for the first time, the room …

Monoclonal antibody purification and its progression to commercial scale

DS Chahar, S Ravindran, SS Pisal - Biologicals, 2020 - Elsevier
With the advancements in upstream technologies, the capacity for monoclonal antibody
(mAb) production has transformed from a few milligrams to grams per liter. These titers lead …

Integrated flow-through purification for therapeutic monoclonal antibodies processing

T Ichihara, T Ito, Y Kurisu, K Galipeau, C Gillespie - MAbs, 2018 - Taylor & Francis
An integrated all flow-through technology platform for the purification of therapeutic
monoclonal antibodies (mAb), consisting of activated carbon and flow-through cation and …

Polishing approach with fully connected flow‐through purification for therapeutic monoclonal antibody

T Ichihara, T Ito, C Gillespie - 2019 - Wiley Online Library
The biopharmaceutical industry is evolving toward process intensification that can offer
increased productivity and improved economics without sacrificing process robustness. A …

Integrated continuous processing of proteins expressed as inclusion bodies: GCSF as a case study

N Kateja, H Agarwal, V Hebbi… - Biotechnology …, 2017 - Wiley Online Library
Affordability of biopharmaceuticals continues to be a challenge, particularly in developing
economies. This has fuelled advancements in manufacturing that can offer higher …

Integrated chromatographic platform for simultaneous separation of charge variants and aggregates from monoclonal antibody therapeutic products

N Kateja, D Kumar, A Godara, V Kumar… - Biotechnology …, 2017 - Wiley Online Library
Achieving consistent product quality of a biotherapeutic is a major target for any
biopharmaceutical manufacturer, even more for a biosimilar producer as comparability with …

The effects of flux on the clearance of minute virus of mice during constant flux virus filtration

R Fan, F Namila, D Sansongko… - Biotechnology and …, 2021 - Wiley Online Library
Constant flux virus filtration experiments were conducted to evaluate minute virus of mice
retention behavior of four commercial virus filters for continuous bioprocessing applications …