Molecular mechanism of lncRNAs in pathogenesis and diagnosis of auto-immune diseases, with a special focus on lncRNA-based therapeutic approaches
Autoimmune diseases are a diverse set of conditions defined by organ damage due to
abnormal innate and acquired immune system responses. The pathophysiology of …
abnormal innate and acquired immune system responses. The pathophysiology of …
Long noncoding RNA Pvt1 regulates the immunosuppression activity of granulocytic myeloid-derived suppressor cells in tumor-bearing mice
Y Zheng, X Tian, T Wang, X Xia, F Cao, J Tian, P Xu… - Molecular cancer, 2019 - Springer
Background Myeloid-derived suppressor cells (MDSCs) participate in tumor-elicited
immunosuppression by dramatically blocking T-cell-induced antitumor responses, thereby …
immunosuppression by dramatically blocking T-cell-induced antitumor responses, thereby …
A long noncoding RNA signature for ulcerative colitis identifies IFNG-AS1 as an enhancer of inflammation
D Padua, S Mahurkar-Joshi, IKM Law… - American Journal …, 2016 - journals.physiology.org
High-throughput technologies revealed new categories of genes, including the long
noncoding RNAs (lncRNAs), involved in the pathogenesis of human disease; however, the …
noncoding RNAs (lncRNAs), involved in the pathogenesis of human disease; however, the …
Long non-coding RNA HOXA transcript antisense RNA myeloid-specific 1–HOXA1 axis downregulates the immunosuppressive activity of myeloid-derived suppressor …
X Tian, J Ma, T Wang, J Tian, Y Zhang, L Mao… - Frontiers in …, 2018 - frontiersin.org
HOXA transcript antisense RNA myeloid-specific 1 (HOTAIRM1) is a long non-coding RNA
that has been shown to be a key regulator of myeloid cell development by targeting HOXA1 …
that has been shown to be a key regulator of myeloid cell development by targeting HOXA1 …
Potential implications of long noncoding RNAs in autoimmune diseases
K Hur, SH Kim, JM Kim - Immune network, 2019 - synapse.koreamed.org
Long noncoding RNAs (lncRNAs) are non-protein coding RNAs of more than 200
nucleotides in length. Despite the term “noncoding”, lncRNAs have been reported to be …
nucleotides in length. Despite the term “noncoding”, lncRNAs have been reported to be …
Disease-associated SNPs in inflammation-related lncRNAs
A Castellanos-Rubio, S Ghosh - Frontiers in immunology, 2019 - frontiersin.org
Immune-mediated diseases, such as celiac disease, type 1 diabetes or multiple sclerosis,
are a clinically heterogeneous group of diseases that share many key genetic triggers …
are a clinically heterogeneous group of diseases that share many key genetic triggers …
Lnc-ITSN1-2, Derived From RNA Sequencing, Correlates With Increased Disease Risk, Activity and Promotes CD4+ T Cell Activation, Proliferation and Th1/Th17 Cell …
J Nie, Q Zhao - Frontiers in immunology, 2020 - frontiersin.org
Background: This study aimed to investigate long-non-coding RNA (lncRNA) expression
profiles and the correlation of lnc-ITSN1-2 expression with disease risk, activity and …
profiles and the correlation of lnc-ITSN1-2 expression with disease risk, activity and …
Novel biomarkers for diagnosis and monitoring of immune thrombocytopenia
Lower-than-normal platelet counts are a hallmark of the acquired autoimmune illness known
as immune thrombocytopenia, which can affect both adults and children. Immune …
as immune thrombocytopenia, which can affect both adults and children. Immune …
The role of long non-coding RNAs in rheumatic diseases
Long non-coding RNAs (lncRNAs) have emerged as key epigenetic regulators that govern
gene expression and influence multiple biological processes. Accumulating evidence …
gene expression and influence multiple biological processes. Accumulating evidence …