Trauma is the leading cause of death in individuals aged 1 to 45 years, with traumatic brain
injury (TBI) responsible for most these deaths; more than 50,000 deaths per year in the …

Abstract Thioredoxins (Trxs), glutaredoxins (Grxs), and peroxiredoxins (Prxs) have been
characterized as electron donors, guards of the intracellular redox state, and “antioxidants” …

Background In patients with traumatic brain injury, hypothermia can reduce intracranial
hypertension. The benefit of hypothermia on functional outcome is unclear. Methods We …

Introduction Evidence-based recommendations are needed to guide the acute management
of the bleeding trauma patient. When these recommendations are implemented patient …

Background: Mild to moderate hypothermia (32–35 C) is the first treatment with proven
efficacy for postischemic neurological injury. In recent years important insights have been …

Introduction Evidence-based recommendations are needed to guide the acute management
of the bleeding trauma patient, which when implemented may improve patient outcomes …

Background Hypothermia therapy improves survival and the neurologic outcome in animal
models of traumatic brain injury. However, the effect of hypothermia therapy on the …

Increasing evidence suggests that induction of mild hypothermia (32–35° C) in the first hours
after an ischaemic event can prevent or mitigate permanent injuries. This effect has been …

Hypothermia in trauma patients is a common condition. It is aggravated by traumatic
hemorrhage, which leads to hypovolemic shock. This hypovolemic shock results in a lethal …

Introduction Evidence-based recommendations can be made with respect to many aspects
of the acute management of the bleeding trauma patient, which when implemented may …