The increasing worldwide prevalence of obesity is partially related to the ready availability of
highly palatable foods which increases the incidence of hedonic, non-homeostatic feeding …

With rising rates of obesity, research continues to explore the contributions of homeostatic
and hedonic mechanisms related to eating behaviour. In this Review, we synthesize the …

For decades the brain was erroneously considered an insulin insensitive organ. Although
gaps in our knowledge base remain, conceptual frameworks are starting to emerge to …

Palatable food can be seductive and hedonic eating can become irresistible beyond hunger
and negative consequences. This is witnessed by the subtle equilibrium between eating to …

Type 2 diabetes and major depressive disorder (MDD) are the leading causes of disability
worldwide and have a high comorbidity rate with fatal outcomes. Despite the long …

Impairment of insulin action and metabolic dysregulation have traditionally been associated
with schizophrenia, although the molecular basis of such association remains still elusive …

Dysfunctional signaling in midbrain reward circuits perpetuates diseases characterized by
compulsive overconsumption of rewarding substances such as substance abuse, binge …

The advances in medicine, together with lifestyle modifications, led to a rising life
expectancy. Unfortunately, however, aging is accompanied by an alarming boost of age …

Emerging evidence associates dysfunction in the dopamine (DA) transporter (DAT) with the
pathophysiology of autism spectrum disorder (ASD). The human DAT (hDAT; SLC6A3) rare …

Diabetes has become a global concern at present, among which type 2 diabetes mellitus
(T2DM) accounts for approximately 90%–95% of patients. T2DM is a type of metabolic …