Toxoplasma gondii is an obligate intracellular protozoan parasite that causes opportunistic
disease, particularly in immunocompromised individuals. Central to its transmission and …

A critical factor in the transmission and pathogenesis of Toxoplasma gondii is the ability to
convert from an acute disease-causing, proliferative stage (tachyzoite), to a chronic, dormant …

Background The obligate intracellular parasite Toxoplasma gondii establishes a life-long
chronic infection within any warm-blooded host. After ingestion of an encysted parasite, T …

Despite their critical role in chronic toxoplasmosis, the biology of Toxoplasma gondii
bradyzoites is poorly understood. In an attempt to address this gap, we optimized …

Toxoplasma gondii proliferates within host cell vacuoles where the parasite relies on host
carbon and nutrients for replication. To assess how T. gondii utilizes these resources, we …

Toxoplasmosis is a prevalent disease affecting a wide range of hosts including
approximately one-third of the human population. It is caused by the sporozoan parasite …

While the apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii are
thought to primarily depend on glycolysis for ATP synthesis, recent studies have shown that …

Background & Aims Intraepithelial lymphocytes that express the γδ T-cell receptor (γδ IELs)
limit pathogen translocation across the intestinal epithelium by unknown mechanisms. We …

Parasitic diseases remain a major public health concern for humans, claiming millions of
lives annually. Although different treatments are required for these diseases, drug usage is …

The nature of energy metabolism in apicomplexan parasites has been closely investigated
in the recent years. Studies in Plasmodium spp. and Toxoplasma gondii in particular have …