Spinal cord injury: molecular mechanisms and therapeutic interventions

X Hu, W Xu, Y Ren, Z Wang, X He, R Huang… - Signal transduction and …, 2023 - nature.com
Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate.
The challenges of SCI repair include its complex pathological mechanisms and the …

Regulation of axonal regeneration after mammalian spinal cord injury

B Zheng, MH Tuszynski - Nature Reviews Molecular Cell Biology, 2023 - nature.com
One hundred years ago, Ramón y Cajal, considered by many as the founder of modern
neuroscience, stated that neurons of the adult central nervous system (CNS) are incapable …

[HTML][HTML] Central nervous system regeneration

SG Varadarajan, JL Hunyara, NR Hamilton… - Cell, 2022 - cell.com
Neurons of the mammalian central nervous system fail to regenerate. Substantial progress
has been made toward identifying the cellular and molecular mechanisms that underlie …

Current advancements in spinal cord Injury Research—glial scar formation and neural regeneration

T Clifford, Z Finkel, B Rodriguez, A Joseph, L Cai - Cells, 2023 - mdpi.com
Spinal cord injury (SCI) is a complex tissue injury resulting in permanent and degenerating
damage to the central nervous system (CNS). Detrimental cellular processes occur after SCI …

Temporal and spatial cellular and molecular pathological alterations with single-cell resolution in the adult spinal cord after injury

C Li, Z Wu, L Zhou, J Shao, X Hu, W Xu… - Signal transduction and …, 2022 - nature.com
Spinal cord injury (SCI) involves diverse injury responses in different cell types in a
temporally and spatially specific manner. Here, using single-cell transcriptomic analyses …

Advances in biomaterial‐based spinal cord injury repair

H Shen, C Fan, Z You, Z Xiao… - Advanced Functional …, 2022 - Wiley Online Library
Spinal cord injury (SCI) often leads to the loss of motor and sensory functions and is a major
challenge in neurological clinical practice. Understanding the pathophysiological changes …

Carbon nanotube–hydrogel composites facilitate neuronal differentiation while maintaining homeostasis of network activity

L Ye, H Ji, J Liu, CH Tu, M Kappl, K Koynov… - Advanced …, 2021 - Wiley Online Library
It is often assumed that carbon nanotubes (CNTs) stimulate neuronal differentiation by
transferring electrical signals and enhancing neuronal excitability. Given this, CNT–hydrogel …

Adhesive, stretchable, and spatiotemporal delivery fibrous hydrogels harness endogenous neural stem/progenitor cells for spinal cord injury repair

Z Chen, H Zhang, C Fan, Y Zhuang, W Yang, Y Chen… - ACS …, 2021 - ACS Publications
Aligned fibrous hydrogels capable of recruiting endogenous neural stem/progenitor cells
(NSPCs) show great promise in spinal cord injury (SCI) repair. However, the hydrogels …

ROS‐Scavenging Hydrogels Synergize with Neural Stem Cells to Enhance Spinal Cord Injury Repair via Regulating Microenvironment and Facilitating Nerve …

D Liu, G Lu, B Shi, H Ni, J Wang, Y Qiu… - Advanced …, 2023 - Wiley Online Library
Although stem cell‐based therapy is recognized as a promising therapeutic strategy for
spinal cord injury (SCI), its efficacy is greatly limited by local reactive oxygen species (ROS) …

Cell therapy for neurological disorders

SP Svendsen, CN Svendsen - Nature Medicine, 2024 - nature.com
Cell therapies for neurological disorders are entering the clinic and present unique
challenges and opportunities compared with conventional medicines. They have the …