Intratumoral heterogeneity is a major ongoing challenge in the effective therapeutic targeting
of cancer. Accumulating evidence suggests that a fraction of cells within a tumor termed …

Metastasis is a dynamic process in which cancer cells navigate the tumor microenvironment,
largely guided by external chemical and mechanical cues. Our current understanding of …

APOBEC cytidine deaminases are the second-most prominent source of mutagenesis in
sequenced tumors. Previous studies have proposed that APOBEC3B (A3B) is the major …

Modern microflow cytometers are sophisticated instruments capable of measuring multiple
physical characteristics of a single cell simultaneously as the cells flow in suspension …

Up to 90% of cancer-related deaths are caused by metastatic cancer. Circulating tumor cells
(CTCs), a type of cancer cell that spreads through the blood after detaching from a solid …

Alterations in mechano-physiological properties of a tissue instigate cancer burdens in
parallel to common genetic and epigenetic alterations. The chronological and mechanistic …

Mesenchymal stem cells (MSC) comprise a heterogeneous population of rapidly
proliferating cells that can be isolated from adult (eg, bone marrow, adipose tissue) as well …

More than 90% of cancer-related deaths can be attributed to the occurrence of metastatic
diseases. Recent studies have highlighted the importance of the multicellular, biochemical …

Collagen is the most abundant component of the extracellular matrix (ECM), therefore it
represents an ideal biomaterial for the culture of a variety of cell types. Recently, collagen …

Tailoring patient‐specific treatments for cancer is necessary in order to achieve optimal
results but requires new diagnostic approaches at affordable prices. Microfluidics has …