Structure and activity of the type VI secretion system

Y Cherrak, N Flaugnatti, E Durand, L Journet… - Microbiology …, 2019 - Am Soc Microbiol
The type VI secretion system (T6SS) is a multiprotein machine that uses a spring-like
mechanism to inject effectors into target cells. The injection apparatus is composed of a …

Human melioidosis

I Gassiep, M Armstrong, R Norton - Clinical microbiology reviews, 2020 - Am Soc Microbiol
The causative agent of melioidosis, Burkholderia pseudomallei, a tier 1 select agent, is
endemic in Southeast Asia and northern Australia, with increased incidence associated with …

Pathogenicity and virulence of Burkholderia pseudomallei

NM Bzdyl, CL Moran, J Bendo, M Sarkar-Tyson - Virulence, 2022 - Taylor & Francis
The soil saprophyte, Burkholderia pseudomallei, is the causative agent of melioidosis, a
disease endemic in South East Asia and northern Australia. Exposure to B. pseudomallei by …

A putative lipoprotein mediates cell-cell contact for type VI secretion system-dependent killing of specific competitors

L Speare, M Woo, AK Dunn, AN Septer - MBio, 2022 - Am Soc Microbiol
Interbacterial competition is prevalent in host-associated microbiota, where it can shape
community structure and function, impacting host health in both positive and negative ways …

Species-specific mechanisms of cytotoxicity toward immune cells determine the successful outcome of Vibrio infections

T Rubio, D Oyanedel, Y Labreuche… - Proceedings of the …, 2019 - National Acad Sciences
Vibrio species cause infectious diseases in humans and animals, but they can also live as
commensals within their host tissues. How Vibrio subverts the host defenses to mount a …

The two-component system FleS/FleR represses H1-T6SS via cyclic di-GMP signaling in Pseudomonas aeruginosa

T Zhou, J Huang, Z Liu, Q Lin, Z Xu… - Applied and …, 2022 - Am Soc Microbiol
The type VI secretion system (T6SS) is an important translocation apparatus that is widely
employed by Gram-negative bacteria to deliver toxic effectors into eukaryotic and prokaryotic …

Wsp system oppositely modulates antibacterial activity and biofilm formation via FleQ‐FleN complex in Pseudomonas putida

H Nie, Y Xiao, M Song, N Wu, Q Peng… - Environmental …, 2022 - Wiley Online Library
Type VI secretion systems (T6SS) are specific antibacterial weapons employed by diverse
bacteria to protect themselves from competitors. Pseudomonas putida KT2440 possesses a …

Type VI secretion systems of plant‐pathogenic Burkholderia glumae BGR1 play a functionally distinct role in interspecies interactions and virulence

N Kim, JJ Kim, I Kim, M Mannaa, J Park… - Molecular Plant …, 2020 - Wiley Online Library
In the environment, bacteria show close association, such as interspecies interaction, with
other bacteria as well as host organisms. The type VI secretion system (T6SS) in gram …

A comprehensive review on the manipulation of the sphingolipid pathway by pathogenic bacteria

M Rolando, C Buchrieser - Frontiers in cell and developmental …, 2019 - frontiersin.org
Bacterial pathogens have developed many different strategies to hijack host cell responses
to promote their own survival. The manipulation of lipid biogenesis and cell membrane …

Unraveling the role of toxin-antitoxin systems in Burkholderia pseudomallei: exploring bacterial pathogenesis and interactions within the HigBA families

I Chapartegui-González, JL Stockton… - Microbiology …, 2024 - journals.asm.org
Burkholderia pseudomallei (Bpm) is a Gram-negative intracellular pathogen that causes
melioidosis in humans, a neglected, underreported, and lethal disease that can reach a fatal …